User profiles for Grace E. Lidgerwood
Grace LidgerwoodResearch Fellow Verified email at unimelb.edu.au Cited by 753 |
[HTML][HTML] Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells
…, SW Lukowski, DE Crombie, GE Lidgerwood… - Genome biology, 2021 - Springer
Background The discovery that somatic cells can be reprogrammed to induced pluripotent
stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug …
stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug …
[HTML][HTML] Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration
There are currently no treatments for geographic atrophy, the advanced form of age-related
macular degeneration. Hence, innovative studies are needed to model this condition and …
macular degeneration. Hence, innovative studies are needed to model this condition and …
[HTML][HTML] Enriched retinal ganglion cells derived from human embryonic stem cells
Optic neuropathies are characterised by a loss of retinal ganglion cells (RGCs) that lead to
vision impairment. Development of cell therapy requires a better understanding of the signals …
vision impairment. Development of cell therapy requires a better understanding of the signals …
[HTML][HTML] Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing
…, Q Wang, JKR Walker, GE Lidgerwood… - Nature …, 2020 - nature.com
Precision genome engineering has dramatically advanced with the development of CRISPR/Cas
base editing systems that include cytosine base editors and adenine base editors (…
base editing systems that include cytosine base editors and adenine base editors (…
[HTML][HTML] Kinase inhibitor screening identifies cyclin-dependent kinases and glycogen synthase kinase 3 as potential modulators of TDP-43 cytosolic accumulation …
Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a
major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or …
major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or …
Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology
Stem cells are unique in their ability to self-renew and differentiate into various cell types.
Because of these features, stem cells are key to the formation of organisms and play …
Because of these features, stem cells are key to the formation of organisms and play …
[HTML][HTML] A village in a dish model system for population-scale hiPSC studies
…, U Nguyen, D Hernández, GE Lidgerwood… - Nature …, 2023 - nature.com
The mechanisms by which DNA alleles contribute to disease risk, drug response, and other
human phenotypes are highly context-specific, varying across cell types and different …
human phenotypes are highly context-specific, varying across cell types and different …
Development of a modular automated system for maintenance and differentiation of adherent human pluripotent stem cells
…, T Kulkarni, F Li, GE Lidgerwood… - … Life Sciences R&D, 2017 - journals.sagepub.com
Patient-specific induced pluripotent stem cells (iPSCs) have tremendous potential for
development of regenerative medicine, disease modeling, and drug discovery. However, the …
development of regenerative medicine, disease modeling, and drug discovery. However, the …
Transcriptomic profiling of human pluripotent stem cell-derived retinal pigment epithelium over time
GE Lidgerwood, A Senabouth… - Genomics …, 2021 - academic.oup.com
Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells,
presenting a potential limitation to the accurate modelling of diseases associated with maturity or …
presenting a potential limitation to the accurate modelling of diseases associated with maturity or …
[HTML][HTML] AAV2-mediated gene therapy for Bietti crystalline dystrophy provides functional CYP4V2 in multiple relevant cell models
Bietti crystalline dystrophy (BCD) is an inherited retinal disease (IRD) caused by mutations in
the CYP4V2 gene. It is a relatively common cause of IRD in east Asia. A number of features …
the CYP4V2 gene. It is a relatively common cause of IRD in east Asia. A number of features …