User profiles for Grace E. Lidgerwood

Grace Lidgerwood

Research Fellow
Verified email at unimelb.edu.au
Cited by 753

[HTML][HTML] Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

…, SW Lukowski, DE Crombie, GE Lidgerwood… - Genome biology, 2021 - Springer
Background The discovery that somatic cells can be reprogrammed to induced pluripotent
stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug …

[HTML][HTML] Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration

A Senabouth, M Daniszewski, GE Lidgerwood… - Nature …, 2022 - nature.com
There are currently no treatments for geographic atrophy, the advanced form of age-related
macular degeneration. Hence, innovative studies are needed to model this condition and …

[HTML][HTML] Enriched retinal ganglion cells derived from human embryonic stem cells

…, A Sharov, CY Lo, K Needham, GE Lidgerwood… - Scientific reports, 2016 - nature.com
Optic neuropathies are characterised by a loss of retinal ganglion cells (RGCs) that lead to
vision impairment. Development of cell therapy requires a better understanding of the signals …

[HTML][HTML] Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing

…, Q Wang, JKR Walker, GE Lidgerwood… - Nature …, 2020 - nature.com
Precision genome engineering has dramatically advanced with the development of CRISPR/Cas
base editing systems that include cytosine base editors and adenine base editors (…

[HTML][HTML] Kinase inhibitor screening identifies cyclin-dependent kinases and glycogen synthase kinase 3 as potential modulators of TDP-43 cytosolic accumulation …

D Moujalled, JL James, SJ Parker, GE Lidgerwood… - PloS one, 2013 - journals.plos.org
Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a
major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or …

Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology

GE Lidgerwood, SM Pitson, C Bonder, A Pébay - Progress in lipid research, 2018 - Elsevier
Stem cells are unique in their ability to self-renew and differentiate into various cell types.
Because of these features, stem cells are key to the formation of organisms and play …

[HTML][HTML] A village in a dish model system for population-scale hiPSC studies

…, U Nguyen, D Hernández, GE Lidgerwood… - Nature …, 2023 - nature.com
The mechanisms by which DNA alleles contribute to disease risk, drug response, and other
human phenotypes are highly context-specific, varying across cell types and different …

Development of a modular automated system for maintenance and differentiation of adherent human pluripotent stem cells

…, T Kulkarni, F Li, GE Lidgerwood… - … Life Sciences R&D, 2017 - journals.sagepub.com
Patient-specific induced pluripotent stem cells (iPSCs) have tremendous potential for
development of regenerative medicine, disease modeling, and drug discovery. However, the …

Transcriptomic profiling of human pluripotent stem cell-derived retinal pigment epithelium over time

GE Lidgerwood, A Senabouth… - Genomics …, 2021 - academic.oup.com
Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells,
presenting a potential limitation to the accurate modelling of diseases associated with maturity or …

[HTML][HTML] AAV2-mediated gene therapy for Bietti crystalline dystrophy provides functional CYP4V2 in multiple relevant cell models

JH Wang, GE Lidgerwood, M Daniszewski, ML Hu… - Scientific Reports, 2022 - nature.com
Bietti crystalline dystrophy (BCD) is an inherited retinal disease (IRD) caused by mutations in
the CYP4V2 gene. It is a relatively common cause of IRD in east Asia. A number of features …