The ordered assembly of tau protein into filaments characterizes several neurodegenerative
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …

Many age-dependent neurodegenerative diseases, such as Alzheimer’s and Parkinson’s,
are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the …

Prion protein (PrP) aggregation and formation of PrP amyloid (APrP) are central events in
the pathogenesis of prion diseases. In the dominantly inherited prion protein amyloidosis …

In human neurodegenerative diseases associated with the intracellular aggregation of Tau
protein, the ordered cores of Tau filaments adopt distinct folds. Here, we analyze Tau …

Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there
is a difference between AD in DS and AD regarding the structure of amyloid-β (Aβ) and tau …

Neurofibrillary tangles, formed of misfolded, hyperphosphorylated tau protein, are a pathological
hallmark of several neurodegenerations, including Alzheimer's disease. Tau pathology …

The aggregation of misfolded tau into neurotoxic fibrils is linked to the progression of
Alzheimer’s disease (AD) and related tauopathies. Disease-associated conformations of …

In neurodegenerative diseases and aging, the microtubuleassociated protein tau (MAPT)
and the transmembrane lysosomal protein 106B (TMEM106B) become misfolded in different …

Directional connectivity is required to develop accurate in vitro models of the nervous system.
This research investigated the interaction of murine neuronal outgrowths with asymmetric …

Aims Frontotemporal dementias are neuropathologically characterised by frontotemporal
lobar degeneration (FTLD). Intraneuronal inclusions of transactive response DNA‐binding …