Despite the increasing global burden of neurological disorders, there is a lack of effective
diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have a …

The human proteome is a crucial intermediate between complex diseases and their genetic
and environmental components, and an important source of drug development targets and …

Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2
(angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection …

Cardiometabolic diseases, such as type 2 diabetes and cardiovascular disease, have a high
public health burden. Understanding the genetically determined regulation of proteins that …

Understanding the genetic basis of neuro-related proteins is essential for dissecting the
disease etiology of neuropsychiatric disorders and other complex traits and diseases. Here, the …

Background Human plasma contains a wide variety of circulating proteins. These proteins
can be important clinical biomarkers in disease and also possible drug targets. Large scale …

Objective Deep sequencing offers unparalleled access to rare variants in human populations.
Understanding their role in disease is a priority, yet prohibitive sequencing costs mean …

Understanding the genetic basis of neuro-related proteins is essential for dissecting the
molecular basis of human behavioral traits and the disease etiology of neuropsychiatric …

Copy number variants (CNVs) play an important role in a number of human diseases, but the
accurate calling of CNVs remains challenging. Most current approaches to CNV detection …

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