The splicing of pre-mRNAs into mature transcripts is remarkable for its precision, but the
mechanisms by which the cellular machinery achieves such specificity are incompletely …

We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n
= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

INTRODUCTION The DNA of protein-coding genes is transcribed into mRNA, which is
translated into proteins. The “coding genome” describes the DNA that contains the information to …

Genomic association studies of common or rare protein-coding variation have established
robust statistical approaches to account for multiple testing. Here we present a comparable …

The combustion of coal to generate electricity produces about 130 million tons of coal
combustion residues (CCRs) each year in the United States; yet their environmental implications …

We sought to determine whether taurine could specifically protect against coronary artery
disease during an atherogenic diet and whether taurine affects the lipid profile, metabolites of …

On-site solid-waste impoundments, landfills, and receiving water bodies have served as
long-term disposal sites for coal combustion residuals (CCRs) across the United States for …

We present the largest exome sequencing study to date focused on rare variation in autism
spectrum disorder (ASD) (n=35,584). Integrating de novo and case-control variation with an …

The unintended release of coal ash to the environment is a concern due to the enrichment
of contaminants such as arsenic (As) and selenium (Se) in this solid waste material. Current …

The chemical composition of coal ash is highly heterogeneous and dependent on the origin
of the source coal, combustion parameters, and type and configuration of air pollution …