… , Muniz-Terrera, and Melzer. Drafting of the manuscript: Llewellyn, Lang, and Muniz-Terrera. …
content: Llewellyn, Lang, Langa, Muniz-Terrera, Phillips, Cherubini, Ferrucci, and Melzer. …

Background: The DNA methylation-based ‘epigenetic clock’ correlates strongly with
chronological age, but it is currently unclear what drives individual differences. We examine cross-…

This study examined the Big Five personality traits as predictors of mortality risk, and smoking
as a mediator of that association. Replication was built into the fabric of our design: we …

Background: the investigation of cognitive decline in the older population has been hampered
by analytical considerations. Most studies of older people over prolonged periods suffer …

Background and Objectives Frailty describes an increased vulnerability to adverse events
such as disease or injury. Combating this state remains a major challenge for geriatric …

Background Alzheimer's disease (AD) is recognized as one of the greatest global public
health challenges. There is increasing consensus that optimal disease modification using …

Recent studies suggest that delirium is associated with risk of dementia and also acceleration
of decline in existing dementia. However, previous studies may have been confounded by …

Numerous models for predicting dementia have been proposed but are limited by a lack of
external validation and evaluation of economic impact. Innovative methods and data designs …

Introduction We estimated the age-specific duration of the preclinical, prodromal, and dementia
stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (…

Background Much of our understanding of the age-related progression of systolic blood
pressure (SBP) comes from cross-sectional data, which do not directly capture within-individual …