User profiles for Grant L Hughes
Grant HughesLiverpool School of Tropical Medicine Verified email at lstmed.ac.uk Cited by 5003 |
[HTML][HTML] Wolbachia Infections Are Virulent and Inhibit the Human Malaria Parasite Plasmodium Falciparum in Anopheles Gambiae
Endosymbiotic Wolbachia bacteria are potent modulators of pathogen infection and transmission
in multiple naturally and artificially infected insect species, including important vectors …
in multiple naturally and artificially infected insect species, including important vectors …
Methods of inactivation of SARS-CoV-2 for downstream biological assays
The scientific community has responded to the coronavirus disease 2019 (COVID-19) pandemic
by rapidly undertaking research to find effective strategies to reduce the burden of this …
by rapidly undertaking research to find effective strategies to reduce the burden of this …
Harnessing mosquito–Wolbachia symbiosis for vector and disease control
Mosquito species, members of the genera Aedes, Anopheles and Culex, are the major
vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of …
vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of …
Native microbiome impedes vertical transmission of Wolbachia in Anopheles mosquitoes
GL Hughes, BL Dodson, RM Johnson… - Proceedings of the …, 2014 - National Acad Sciences
Over evolutionary time, Wolbachia has been repeatedly transferred between host species
contributing to the widespread distribution of the symbiont in arthropods. For novel infections …
contributing to the widespread distribution of the symbiont in arthropods. For novel infections …
[HTML][HTML] Wolbachia Enhances West Nile Virus (WNV) Infection in the Mosquito Culex tarsalis
BL Dodson, GL Hughes, O Paul… - PLoS neglected …, 2014 - journals.plos.org
Novel strategies are required to control mosquitoes and the pathogens they transmit. One
attractive approach involves maternally inherited endosymbiotic Wolbachia bacteria. After …
attractive approach involves maternally inherited endosymbiotic Wolbachia bacteria. After …
The microbiome modulates arbovirus transmission in mosquitoes
Highlights • Complex interactions occur within the mosquito holobiome that profoundly alter
the phenotype of the host. • Bacteria can enhance or suppress arbovirus transmission in …
the phenotype of the host. • Bacteria can enhance or suppress arbovirus transmission in …
[HTML][HTML] Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing
Cas9-mediated gene editing is a powerful tool for addressing research questions in arthropods.
Current approaches rely upon delivering Cas9 ribonucleoprotein (RNP) complex by …
Current approaches rely upon delivering Cas9 ribonucleoprotein (RNP) complex by …
[HTML][HTML] Limit of detection in different matrices of 19 commercially available rapid antigen tests for the detection of SARS-CoV-2
…, CT Williams, EI Patterson, GL Hughes, L Baldwin… - Scientific reports, 2021 - nature.com
In the context of the coronavirus disease 2019 (COVID-19) pandemic there has been an
increase of the use of antigen-detection rapid diagnostic tests (Ag-RDT). The performance of Ag-…
increase of the use of antigen-detection rapid diagnostic tests (Ag-RDT). The performance of Ag-…
Transinfection: a method to investigate Wolbachia–host interactions and control arthropod‐borne disease
The bacterial endosymbiont W olbachia manipulates arthropod host biology in numerous
ways, including sex ratio distortion and differential offspring survival. These bacteria infect a …
ways, including sex ratio distortion and differential offspring survival. These bacteria infect a …
[HTML][HTML] SARS-CoV-2 infections in animals: reservoirs for reverse zoonosis and models for study
The recent SARS-CoV-2 pandemic has brought many questions over the origin of the virus,
the threat it poses to animals both in the wild and captivity, and the risks of a permanent viral …
the threat it poses to animals both in the wild and captivity, and the risks of a permanent viral …