User profiles for Grant L Hughes

Grant Hughes

Liverpool School of Tropical Medicine
Verified email at lstmed.ac.uk
Cited by 5003

[HTML][HTML] Wolbachia Infections Are Virulent and Inhibit the Human Malaria Parasite Plasmodium Falciparum in Anopheles Gambiae

GL Hughes, R Koga, P Xue, T Fukatsu… - PLoS …, 2011 - journals.plos.org
Endosymbiotic Wolbachia bacteria are potent modulators of pathogen infection and transmission
in multiple naturally and artificially infected insect species, including important vectors …

Methods of inactivation of SARS-CoV-2 for downstream biological assays

…, Á Acosta-Serrano, L Turtle, GL Hughes - The Journal of …, 2020 - academic.oup.com
The scientific community has responded to the coronavirus disease 2019 (COVID-19) pandemic
by rapidly undertaking research to find effective strategies to reduce the burden of this …

Harnessing mosquito–Wolbachia symbiosis for vector and disease control

…, HC Bossin, R Moretti, LA Baton, GL Hughes… - Acta tropica, 2014 - Elsevier
Mosquito species, members of the genera Aedes, Anopheles and Culex, are the major
vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of …

Native microbiome impedes vertical transmission of Wolbachia in Anopheles mosquitoes

GL Hughes, BL Dodson, RM Johnson… - Proceedings of the …, 2014 - National Acad Sciences
Over evolutionary time, Wolbachia has been repeatedly transferred between host species
contributing to the widespread distribution of the symbiont in arthropods. For novel infections …

[HTML][HTML] Wolbachia Enhances West Nile Virus (WNV) Infection in the Mosquito Culex tarsalis

BL Dodson, GL Hughes, O Paul… - PLoS neglected …, 2014 - journals.plos.org
Novel strategies are required to control mosquitoes and the pathogens they transmit. One
attractive approach involves maternally inherited endosymbiotic Wolbachia bacteria. After …

The microbiome modulates arbovirus transmission in mosquitoes

S Hegde, JL Rasgon, GL Hughes - Current opinion in virology, 2015 - Elsevier
Highlights • Complex interactions occur within the mosquito holobiome that profoundly alter
the phenotype of the host. • Bacteria can enhance or suppress arbovirus transmission in …

[HTML][HTML] Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing

D Chaverra-Rodriguez, VM Macias, GL Hughes… - Nature …, 2018 - nature.com
Cas9-mediated gene editing is a powerful tool for addressing research questions in arthropods.
Current approaches rely upon delivering Cas9 ribonucleoprotein (RNP) complex by …

[HTML][HTML] Limit of detection in different matrices of 19 commercially available rapid antigen tests for the detection of SARS-CoV-2

…, CT Williams, EI Patterson, GL Hughes, L Baldwin… - Scientific reports, 2021 - nature.com
In the context of the coronavirus disease 2019 (COVID-19) pandemic there has been an
increase of the use of antigen-detection rapid diagnostic tests (Ag-RDT). The performance of Ag-…

Transinfection: a method to investigate Wolbachia–host interactions and control arthropod‐borne disease

GL Hughes, JL Rasgon - Insect molecular biology, 2014 - Wiley Online Library
The bacterial endosymbiont W olbachia manipulates arthropod host biology in numerous
ways, including sex ratio distortion and differential offspring survival. These bacteria infect a …

[HTML][HTML] SARS-CoV-2 infections in animals: reservoirs for reverse zoonosis and models for study

…, SL Smith, AD Radford, T Solomon, GL Hughes… - Viruses, 2021 - mdpi.com
The recent SARS-CoV-2 pandemic has brought many questions over the origin of the virus,
the threat it poses to animals both in the wild and captivity, and the risks of a permanent viral …