… Grant N Wheeler … All ADAMTSs with the exception of ADAMTS4 are N-glycosylated at
NxS/T sites, with N-glycosylation within the pro-domain of ADAMTS9 being necessary for its …

Melanoma is a tumour of transformed melanocytes, which are originally derived from the
embryonic neural crest. It is unknown to what extent the programs that regulate neural crest …

Chemical genetics uses small molecules to modulate protein function and, in principle, has
the potential to perturb any biochemical event in a complex cellular context. The application …

Hemidesmosomes are stable adhesion complexes in basal epithelial cells that provide a
link between the intermediate filament network and the extracellular matrix. We have …

For successful regeneration, the identity of the missing tissue must be specified according to
the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this …

The neural crest is a multipotent cell population that migrates from the dorsal edge of the
neural tube to various parts of the embryo where it differentiates into a remarkable variety of …

Myogenesis involves the stable commitment of progenitor cells followed by the execution of
myogenic differentiation, processes that are coordinated by myogenic regulatory factors, …

Novel alternatives to antibiotics are urgently needed for the successful treatment of antimicrobial
resistant (AMR) infections. Experimental antibacterial oligonucleotide therapeutics, …

The microRNAs (miRNAs) are recently discovered short, noncoding RNAs, that regulate
gene expression in metazoans. We have cloned short RNAs from chicken embryos and …

We have cloned the human genes coding for desmosomal glycoproteins DGII and DGIII, found
in desmosomal cell junctions, and sequencing shows that they are related to the cadherin …