Although melanoma is notorious for its high degree of heterogeneity and plasticity 1 , 2 , the
origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear …

Therapy resistance arises from heterogeneous drug-tolerant persister cells or minimal residual
disease (MRD) through genetic and nongenetic mechanisms. A key question is whether …

To better understand intrinsic resistance to immune checkpoint blockade (ICB), we established
a comprehensive view of the cellular architecture of the treatment-naive melanoma …

NEAT1 is one of the most studied lncRNAs, in part because its silencing in mice causes
defects in mammary gland development and corpus luteum formation and protects them from …

Induction and reversal of chromatin silencing is critical for successful development, tissue
homeostasis, and the derivation of induced pluripotent stem cells (iPSCs). X-Chromosome …

Background Precise gene dosage of the X chromosomes is critical for normal development
and cellular function. In mice, XX female somatic cells show transcriptional X chromosome …

Primary resistance drastically limits the clinical success of immune checkpoint blockade (ICB)
in melanoma. Resistance to ICB may also develop when tumours relapse after targeted …

Immune checkpoint blockade (ICB) has become a standard of care in the treatment of
metastatic melanoma (MM). Although ICB is particularly successful in some MM patients, more …

The ability to predict the future behaviour of an individual cancer is crucial for precision cancer
medicine and, in particular, for the development of strategies that prevent acquisition of …

… 2 , Greet Bervoets …