User profiles for Greg Finak
Greg FinakCTO, Ozette Technologies Verified email at ozette.ai Cited by 9044 |
[HTML][HTML] MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic
dropout and characteristic bimodal expression distributions in which expression is either …
dropout and characteristic bimodal expression distributions in which expression is either …
Stromal gene expression predicts clinical outcome in breast cancer
Although it is increasingly evident that cancer is influenced by signals emanating from tumor
stroma, little is known regarding how changes in stromal gene expression affect epithelial …
stroma, little is known regarding how changes in stromal gene expression affect epithelial …
[HTML][HTML] Critical assessment of automated flow cytometry data analysis techniques
N Aghaeepour, G Finak, FlowCAP Consortium… - Nature …, 2013 - nature.com
Traditional methods for flow cytometry (FCM) data processing rely on subjective manual
gating. Recently, several groups have developed computational methods for identifying cell …
gating. Recently, several groups have developed computational methods for identifying cell …
Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial
…, U Gnad-Vogt, HS Hong, KT Mehr, L Backert, G Finak… - The Lancet, 2017 - thelancet.com
Background Vaccines based on mRNA coding for antigens have been shown to be safe and
immunogenic in preclinical models. We aimed to report results of the first-in-human proof-of-…
immunogenic in preclinical models. We aimed to report results of the first-in-human proof-of-…
Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments
Motivation: Cell populations are never truly homogeneous; individual cells exist in
biochemical states that define functional differences between them. New technology based on …
biochemical states that define functional differences between them. New technology based on …
Vaccination induces HIV broadly neutralizing antibody precursors in humans
Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …
[HTML][HTML] Standardizing flow cytometry immunophenotyping analysis from the human immunophenotyping consortium
G Finak, M Langweiler, M Jaimes, M Malek… - Scientific reports, 2016 - nature.com
Standardization of immunophenotyping requires careful attention to reagents, sample handling,
instrument setup, and data analysis, and is essential for successful cross-study and cross…
instrument setup, and data analysis, and is essential for successful cross-study and cross…
COMPASS identifies T-cell subsets correlated with clinical outcomes
Advances in flow cytometry and other single-cell technologies have enabled high-dimensional,
high-throughput measurements of individual cells as well as the interrogation of cell …
high-throughput measurements of individual cells as well as the interrogation of cell …
Regulation of endocytosis via the oxygen-sensing pathway
Tumor hypoxia is associated with disease progression, resistance to conventional cancer
therapies and poor prognosis 1 , 2 . Hypoxia, by largely unknown mechanisms, leads to …
therapies and poor prognosis 1 , 2 . Hypoxia, by largely unknown mechanisms, leads to …
[HTML][HTML] OpenCyto: an open source infrastructure for scalable, robust, reproducible, and automated, end-to-end flow cytometry data analysis
Flow cytometry is used increasingly in clinical research for cancer, immunology and
vaccines. Technological advances in cytometry instrumentation are increasing the size and …
vaccines. Technological advances in cytometry instrumentation are increasing the size and …