Nafion-coated electrodes with high selectivity for CNS electrochemistry

GA Gerhardt, AF Oke, G Nagy, B Moghaddam… - Brain research, 1984 - Elsevier
A major improvement in the selectivity of small graphite electrodes used for in vivo electrochemistry
is described. The electrodes are coated with Nafion, a perfluorosulfonated polymer. …

Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo

…, P Huettl, J Hudson, D Martin, LFH Lin, GA Gerhardt - Neuroscience …, 1994 - Elsevier
Fischer 344 rats were unilaterally injected into the medial forebrain bundle with 6-hydroxydopamine
(6-OHDA). Apomorphine-induced rotational behavior was used to select animals …

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

…, Z Zhang, DM Gash, GA Gerhardt… - Proceedings of the …, 2004 - National Acad Sciences
We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor
dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were …

Self-Referencing Ceramic-Based Multisite Microelectrodes for the Detection and Elimination of Interferences from the Measurement of l-Glutamate and Other Analytes

JJ Burmeister, GA Gerhardt - Analytical chemistry, 2001 - ACS Publications
A self-referencing technique utilizing two microelectrodes on a ceramic-based multisite
array is employed for confirmation and elimination of interferences detected by enzyme-based …

Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys

…, AH Andersen, DD Elsberry, MC Klein, GA Gerhardt… - Brain, 2002 - academic.oup.com
The powerful trophic effects that glial cell line‐derived neurotrophic factor (GDNF) exerts on
midbrain dopamine neurones suggest its use in treating Parkinson’s disease. However, …

o-Phenylenediamine-Modified Carbon Fiber Electrodes for the Detection of Nitric Oxide

…, SW Robinson, GA Gerhardt - Analytical chemistry, 1996 - ACS Publications
Nitric oxide (NO • ) sensors were prepared using o-phenylenediamine (o-PD) and Nafion to
modify the surface of 30 μm diameter carbon fiber electrodes. These electrodes were …

Neurobiological studies of sensory gating in schizophrenia

R Freedman, LE Adler, GA Gerhardt… - Schizophrenia …, 1987 - academic.oup.com
The sensory disturbance in schizophrenia is often described as an inability to filter out
extraneous noise from meaningful sensory inputs. The neurobiological basis of this inability to …

Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line—derived neurotrophic factor

JT Slevin, GA Gerhardt, CD Smith, DM Gash… - Journal of …, 2005 - thejns.org
Object. Glial cell line-derived neurotrophic factor (GDNF) has demonstrated significant
antiparkinsonian actions in several animal models and in a recent pilot study in England in which …

Correlation of apomorphine-and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats

…, J Clayton, J Masserano, BJ Hoffer, GA Gerhardt - Brain research, 1993 - Elsevier
In the unilateral 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease,
controversy exists concerning the use of apomorphine- ord-amphetamine-induced rotations …

Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level

…, M Cecchi, DA Morilak, GA Gerhardt… - Journal of …, 1999 - Soc Neuroscience
To investigate functional changes in the brain serotonin transporter (SERT) after chronic
antidepressant treatment, several techniques were used to assess SERT activity, density, or its …