[HTML][HTML] Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants

…, OG John, PE Eromon, G Kocher… - Nature biomedical …, 2022 - nature.com
The widespread transmission and evolution of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) call for rapid nucleic acid diagnostics that are easy to use outside of …

Clinical, virologic, and immunologic evaluation of symptomatic coronavirus disease 2019 rebound following nirmatrelvir/ritonavir treatment

…, J Highbarger, A Rupert, G Kocher… - Clinical Infectious …, 2023 - academic.oup.com
Background Nirmatrelvir/ritonavir, the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
protease inhibitor, reduces the risk of hospitalization and death by …

[HTML][HTML] Characteristic and quantifiable COVID-19-like abnormalities in CT-and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (Macaca …

…, J Liang, K Sharer, J Solomon, PJ Sayre, G Kocher… - BioRxiv, 2020 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing an exponentially
increasing number of coronavirus disease 19 (COVID-19) cases globally. Prioritization of …

[HTML][HTML] Scalable, micro-neutralization assay for assessment of SARS-CoV-2 (COVID-19) virus-neutralizing antibodies in human clinical samples

…, J Liang, R Gross, S Mazur, S Dixit, G Kocher… - Viruses, 2021 - mdpi.com
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic expanded,
it was clear that effective testing for the presence of neutralizing antibodies in the blood of …

[HTML][HTML] Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties

…, Y Cai, S Yu, CO Smith, J Liang, H Zhou, GA Kocher… - JCI insight, 2022 - ncbi.nlm.nih.gov
Sangivamycin is a nucleoside analog that is well tolerated by humans and broadly active
against phylogenetically distinct viruses, including arenaviruses, filoviruses, and …

Immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccination in exposed and potentially exposed persons in the Democratic Republic of the Congo

…, B Dighero-Kemp, G Kocher… - Proceedings of the …, 2022 - National Acad Sciences
Despite more than 300,000 rVSVΔG-ZEBOV-glycoprotein (GP) vaccine doses having been
administered during Ebola virus disease (EVD) outbreaks in the Democratic Republic of the …

[HTML][HTML] Equipment-free detection of SARS-CoV-2 and Variants of Concern using Cas13

…, G Kim, JN Uwanibe, OG John, PE Eromon, G Kocher… - medrxiv, 2021 - ncbi.nlm.nih.gov
The COVID-19 pandemic, and the recent rise and widespread transmission of SARS-CoV-2
Variants of Concern (VOCs), have demonstrated the need for ubiquitous nucleic acid testing …

[HTML][HTML] COVID-19 redux: clinical, virologic, and immunologic evaluation of clinical rebound after nirmatrelvir/ritonavir

…, T Rehman, J Highbarger, A Rupert, G Kocher… - medRxiv, 2022 - ncbi.nlm.nih.gov
Clinical rebound of COVID-19 after nirmatrelvir/ritonavir treatment has been reported. We
performed clinical, virologic, and immune measurements in seven patients with symptomatic …

Evaluation of TRIzol LS inactivation of viruses

TJ Kochel, GA Kocher, TG Ksiazek, JP Burans - Applied Biosafety, 2017 - liebertpub.com
Prior to the release from BSL-3 or -4 laboratories, materials from which nucleic acids are to
be extracted must be rendered noninfectious. Typically, phenol/guanidine thiocyanate …

Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients

…, MA Pearson, W Sommergruber, GJ Kocher… - …, 2022 - Taylor & Francis
Antibody-mediated cancer immunotherapy targets inhibitory surface molecules, such as
PD1, PD-L1, and CTLA-4, aiming to re-invigorate dysfunctional T cells. We purified and …