User profiles for Gregoire Courtine
Gregoire COURTINEDirector, .NeuroRestore, Swiss Federal Institute of Technology (EPFL) Verified email at epfl.ch Cited by 19026 |
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …
Targeted neurotechnology restores walking in humans with spinal cord injury
Spinal cord injury leads to severe locomotor deficits or even complete leg paralysis. Here we
introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control …
introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control …
Restoring voluntary control of locomotion after paralyzing spinal cord injury
Half of human spinal cord injuries lead to chronic paralysis. Here, we introduce an
electrochemical neuroprosthesis and a robotic postural interface designed to encourage …
electrochemical neuroprosthesis and a robotic postural interface designed to encourage …
Electronic dura mater for long-term multimodal neural interfaces
The mechanical mismatch between soft neural tissues and stiff neural implants hinders the
long-term performance of implantable neuroprostheses. Here, we designed and fabricated …
long-term performance of implantable neuroprostheses. Here, we designed and fabricated …
A computational model for epidural electrical stimulation of spinal sensorimotor circuits
Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements
after spinal cord injury. However, the mechanisms and neural structures through which …
after spinal cord injury. However, the mechanisms and neural structures through which …
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
G Courtine, Y Gerasimenko, R Van Den Brand… - Nature …, 2009 - nature.com
After complete spinal cord transections that removed all supraspinal inputs in adult rats,
combinations of serotonergic agonists and epidural electrical stimulation were able to acutely …
combinations of serotonergic agonists and epidural electrical stimulation were able to acutely …
A brain–spine interface alleviating gait deficits after spinal cord injury in primates
Spinal cord injury disrupts the communication between the brain and the spinal circuits that
orchestrate movement. To bypass the lesion, brain–computer interfaces 1 , 2 , 3 have directly …
orchestrate movement. To bypass the lesion, brain–computer interfaces 1 , 2 , 3 have directly …
[PDF][PDF] Muscle spindle feedback directs locomotor recovery and circuit reorganization after spinal cord injury
A Takeoka, I Vollenweider, G Courtine, S Arber - Cell, 2014 - cell.com
Spinal cord injuries alter motor function by disconnecting neural circuits above and below
the lesion, rendering sensory inputs a primary source of direct external drive to neuronal …
the lesion, rendering sensory inputs a primary source of direct external drive to neuronal …
Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury
G Courtine, B Song, RR Roy, H Zhong, JE Herrmann… - Nature medicine, 2008 - nature.com
Spinal cord injuries (SCIs) in humans 1 , 2 and experimental animals 3 , 4 , 5 , 6 are often
associated with varying degrees of spontaneous functional recovery during the first months …
associated with varying degrees of spontaneous functional recovery during the first months …
Spinal cord repair: advances in biology and technology
G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but no …
Advances in clinical management have decreased morbidity and improved outcomes, but no …
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