User profiles for Gregoire Courtine

Gregoire COURTINE

Director, .NeuroRestore, Swiss Federal Institute of Technology (EPFL)
Verified email at epfl.ch
Cited by 19026

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

…, L Asboth, FB Wagner, J Bloch, G Courtine - Nature medicine, 2022 - nature.com
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …

Targeted neurotechnology restores walking in humans with spinal cord injury

…, H Lambert, K Minassian, J Bloch, G Courtine - Nature, 2018 - nature.com
Spinal cord injury leads to severe locomotor deficits or even complete leg paralysis. Here we
introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control …

Restoring voluntary control of locomotion after paralyzing spinal cord injury

…, S Duis, N Dominici, S Micera, P Musienko, G Courtine - science, 2012 - science.org
Half of human spinal cord injuries lead to chronic paralysis. Here, we introduce an
electrochemical neuroprosthesis and a robotic postural interface designed to encourage …

Electronic dura mater for long-term multimodal neural interfaces

…, A Larmagnac, J Vörös, S Micera, Z Suo, G Courtine… - Science, 2015 - science.org
The mechanical mismatch between soft neural tissues and stiff neural implants hinders the
long-term performance of implantable neuroprostheses. Here, we designed and fabricated …

A computational model for epidural electrical stimulation of spinal sensorimotor circuits

…, J Beauparlant, LB Luciani, G Courtine… - Journal of …, 2013 - Soc Neuroscience
Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements
after spinal cord injury. However, the mechanisms and neural structures through which …

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

G Courtine, Y Gerasimenko, R Van Den Brand… - Nature …, 2009 - nature.com
After complete spinal cord transections that removed all supraspinal inputs in adult rats,
combinations of serotonergic agonists and epidural electrical stimulation were able to acutely …

A brain–spine interface alleviating gait deficits after spinal cord injury in primates

…, T Denison, S Micera, E Bezard, J Bloch, G Courtine - Nature, 2016 - nature.com
Spinal cord injury disrupts the communication between the brain and the spinal circuits that
orchestrate movement. To bypass the lesion, brain–computer interfaces 1 , 2 , 3 have directly …

[PDF][PDF] Muscle spindle feedback directs locomotor recovery and circuit reorganization after spinal cord injury

A Takeoka, I Vollenweider, G Courtine, S Arber - Cell, 2014 - cell.com
Spinal cord injuries alter motor function by disconnecting neural circuits above and below
the lesion, rendering sensory inputs a primary source of direct external drive to neuronal …

Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury

G Courtine, B Song, RR Roy, H Zhong, JE Herrmann… - Nature medicine, 2008 - nature.com
Spinal cord injuries (SCIs) in humans 1 , 2 and experimental animals 3 , 4 , 5 , 6 are often
associated with varying degrees of spontaneous functional recovery during the first months …

Spinal cord repair: advances in biology and technology

G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but no …