… Viglianti, Ian R. Rifkin, Ann Marshak-Rothstein; RNA-associated autoantigens activate B
cells by combined B cell antigen receptor/Toll-like receptor 7 engagement . J Exp Med 7 …

The proliferative response of autoreactive rheumatoid factor (RF) B cells to mammalian
chromatin-containing immune complexes (ICs) results from the sequential engagement of the B …

Yeast Saccharomyces cerevisiae strains that are permeable to the antitumor alkaloid
camptothecin are killed by the drug if they express DNA topoisomerase I, the cellular target of the …

We previously reported that monoclonal antibodies to protein-disulfide isomerase (PDI) and
other membrane-impermeant PDI inhibitors prevented HIV-1 infection. PDI is present at the …

Although TLR9 was originally thought to specifically recognize microbial DNA, it is now
evident that mammalian DNA can be an effective TLR9 ligand. However, the DNA sequence …

Dendritic cells (DCs) contribute to human immunodeficiency virus type 1 (HIV-1) transmission
and dissemination by capturing and transporting infectious virus from the mucosa to …

Autoreactive B cells are activated by DNA, chromatin, or chromatin-containing immune
complexes (ICs) through a mechanism dependent on dual engagement of the BCR and TLR9. …

IL-16 is produced by CD8+ lymphocytes and has been reported to inhibit HIV-1 and SIV
replication in infected PBMCs. CD4 serves as a receptor for the secreted form of IL-16, and IL-16 …

Sexually transmitted pathogens activate HIV-1 replication and inflammatory gene
expression in macrophages through engagement of Toll-like receptors (TLRs). Ligand-activated …

Although much is now known of the strain variation among the type-1 human immunodeficiency
virus (HIV-1), which is the cause of AIDS (acquired immune deficiency syndrome) in the …