We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional
(3D) genome architectures at the chromosome scale. Each type appears and …

Echinobase ( www.echinobase.org ) is a third generation web resource supporting genomic
research on echinoderms. The new version was built by cloning the mature Xenopus model …

The extensive array of morphological diversity among animal taxa represents the product of
millions of years of evolution. Morphology is the output of development, therefore phenotypic …

Background Metazoan lineages exhibit a wide range of regenerative capabilities that vary
among developmental stage and tissue type. The most robust regenerative abilities are …

The highly recognizable animals within the phylum Echinodermata encompass an
enormous disparity of adult and larval body plans. The extensive knowledge of sea urchin …

The echinoderms are a phylum of invertebrate deuterostome animals that constitute
important research models for a number of biological disciplines. EchinoBase ( www.echinobase.…

Understanding how changes in developmental gene expression alter morphogenesis is a
fundamental problem in development and evolution. A promising approach to address this …

Sea stars and sea urchins are model systems for interrogating the types of deep evolutionary
changes that have restructured developmental gene regulatory networks (GRNs). Although …

Polyglutamine repeat expansion in the androgen receptor is responsible for the motor neuron
degeneration in X-linked spinal and bulbar muscular atrophy (SBMA; Kennedy's disease). …

P-bodies (PB) are ribonucleoprotein (RNP) complexes that aggregate into cytoplasmic foci
when cells are exposed to stress. Although the conserved mRNA decay and translational …