Flanking polyproline sequences inhibit β-sheet structure in polyglutamine segments by inducing PPII-like helix structure
G Darnell, JPRO Orgel, R Pahl, SC Meredith - Journal of molecular biology, 2007 - Elsevier
Polyglutamine (poly(Q)) expansion is associated with protein aggregation into β-sheet amyloid
fibrils and neuronal cytotoxicity. In the mutant poly(Q) protein huntingtin, associated with …
fibrils and neuronal cytotoxicity. In the mutant poly(Q) protein huntingtin, associated with …
[HTML][HTML] Sparse multi-output Gaussian processes for online medical time series prediction
Background For real-time monitoring of hospital patients, high-quality inference of patients’
health status using all information available from clinical covariates and lab test results is …
health status using all information available from clinical covariates and lab test results is …
[HTML][HTML] Joint analysis of expression levels and histological images identifies genes associated with tissue morphology
Histopathological images are used to characterize complex phenotypes such as tumor stage.
Our goal is to associate features of stained tissue images with high-dimensional genomic …
Our goal is to associate features of stained tissue images with high-dimensional genomic …
[PDF][PDF] Mechanism of cis-inhibition of polyQ fibrillation by polyP: PPII oligomers and the hydrophobic effect
GD Darnell, JM Derryberry, JW Kurutz, SC Meredith - Biophysical journal, 2009 - cell.com
PolyQ peptides teeter between polyproline II (PPII) and β-sheet conformations. In tandem
polyQ-polyP peptides, the polyP segment tips the balance toward PPII, increasing the …
polyQ-polyP peptides, the polyP segment tips the balance toward PPII, increasing the …
Statistical tests for detecting variance effects in quantitative trait studies
Motivation Identifying variants, both discrete and continuous, that are associated with
quantitative traits, or QTs, is the primary focus of quantitative genetics. Most current methods are …
quantitative traits, or QTs, is the primary focus of quantitative genetics. Most current methods are …
[HTML][HTML] Multi-scale inference of genetic trait architecture using biologically annotated neural networks
In this article, we present Biologically Annotated Neural Networks (BANNs), a nonlinear
probabilistic framework for association mapping in genome-wide association (GWA) studies. …
probabilistic framework for association mapping in genome-wide association (GWA) studies. …
Incorporating prior information into association studies
Recent technological developments in measuring genetic variation have ushered in an era
of genome-wide association studies which have discovered many genes involved in human …
of genome-wide association studies which have discovered many genes involved in human …
[HTML][HTML] Modeling personalized heart rate response to exercise and environmental factors with wearables data
Heart rate (HR) response to workout intensity reflects fitness and cardiorespiratory health.
Physiological models have been developed to describe such heart rate dynamics and …
Physiological models have been developed to describe such heart rate dynamics and …
Accounting for statistical non-additive interactions enables the recovery of missing heritability from GWAS summary statistics
LD score regression ( LDSC ) is a method to estimate narrow-sense heritability from genome-wide
association study (GWAS) summary statistics alone, making it a fast and popular …
association study (GWAS) summary statistics alone, making it a fast and popular …
Adaptive randomized dimension reduction on massive data
G Darnell, S Georgiev, S Mukherjee… - Journal of Machine …, 2017 - jmlr.org
The scalability of statistical estimators is of increasing importance in modern applications. One
approach to implementing scalable algorithms is to compress data into a low dimensional …
approach to implementing scalable algorithms is to compress data into a low dimensional …