▪ Abstract The crucial role of L-type Ca 2+ channels in the initiation of cardiac and smooth
muscle contraction has made them major therapeutic targets for the treatment of …

Plant defensins are a family of small Cys-rich antifungal proteins that play important roles in
plant defense against invading fungi. Structures of several plant defensins share a Cys-…

Synaptic transmission is regulated by G protein-coupled receptors whose activation releases
G protein βγ subunits that modulate presynaptic Ca 2+ channels. The sequence motif …

The high affinity phenylalkylamine(-)D888 blocks ion currents through L-type Ca 2+ channels
containing the α 1C subunit with an apparent K d of 50 nM, but N-type Ca 2+ channels in …

The design, synthesis, biological evaluation, and in vivo studies of difluoromethyl ketones
as GABA B agonists that are not structurally analogous to known GABA B agonists, such as …

Recent studies of the phenylalkylamine binding site in the α 1C subunit of l-type Ca 2+
channels have revealed three amino acid residues in transmembrane segment IVS6 that are …

The activity of l-type Ca 2+ channels is increased by dihydropyridine (DHP) agonists and
inhibited by DHP antagonists, which are widely used in the therapy of cardiovascular disease. …

Since the discovery of the GABA B agonist and muscle relaxant baclofen, there have been
substantial advancements in the development of compounds that activate the GABA B …

The dihydropyridine Ca 2+ antagonist drugs used in the therapy of cardiovacular disorders
inhibitl-type Ca 2+ channels by binding to a single high affinity site. Photoaffinity labeling and …

The benzothiazepine diltiazem blocks ionic current through L-type Ca 2+ channels, as do
the dihydropyridines (DHPs) and phenylalkylamines (PAs), but it has unique properties that …