Obesity is a major cancer risk factor, but how differences in systemic metabolism change the
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …

Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the
production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis …

Highly multiplexed tissue imaging makes detailed molecular analysis of single cells possible
in a preserved spatial context. However, reproducible analysis of large multichannel …

Abstract Treatment of BRAF ‐mutant melanomas with MAP kinase pathway inhibitors is
paradigmatic of the promise of precision cancer therapy but also highlights problems with drug …

Purpose: Dexamethasone, a uniquely potent corticosteroid, is frequently administered to
patients with brain tumors to decrease tumor-associated edema, but limited data exist …

As glioma cells infiltrate the brain they become associated with various microanatomic brain
structures such as blood vessels, white matter tracts, and brain parenchyma. How these …

Targeted inhibition of oncogenic pathways can be highly effective in halting the rapid
growth of tumors but often leads to the emergence of slowly dividing persister cells, which …

We surveyed 10 years of CANOPUS Churchill line magnetometer data for Pc5 pulsations
and catalogued over 4500 hours of pulsation activity (3334 Pc5 pulsation intervals). Many …

How the glioma immune microenvironment fosters tumorigenesis remains incompletely
defined. Here, we use single-cell RNA-sequencing and multiplexed tissue-imaging to …

Glioblastoma (GBM) is a highly invasive brain tumor. Perivascular invasion, autovascularization
and vascular co-option occur throughout the disease and lead to tumor invasion and …