The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has demonstrated
potential for treatment of various cancers 1 , 2 , 3 , 4 , 5 , 6 – 7 . However, little is known …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

The cell surface nucleotidase CD73 is an immunosuppressive enzyme involved in tumor
progression and metastasis. Although preclinical studies suggest that CD73 can be targeted for …

To improve clinical outcomes for CAR T-cell therapy, there is a need to understand the
molecular determinants of CAR T-cell persistence. These data represent the largest clinically …

Polyketides (PKs) and nonribosomal peptides (NRPs) are profoundly important natural
products, forming the foundations of many therapeutic regimes. Decades of research have …

The histopathological evaluation of morphological features in breast tumours provides
prognostic information to guide therapy. Adjunct molecular analyses provide further diagnostic, …

Antibiotics are essential for numerous medical procedures, including the treatment of bacterial
infections, but their widespread use has led to the accumulation of resistance, prompting …

Purpose: The majority of ovarian carcinomas are of high-grade serous histology, which is
associated with poor prognosis. Surgery and chemotherapy are the mainstay of treatment, and …

Background We introduce BPG, a framework for generating publication-quality, highly-customizable
plots in the R statistical environment. Results This open-source package includes …

A major limitation of chimeric antigen receptor (CAR) T cell therapies is the poor persistence
of these cells in vivo 1 . The expression of memory-associated genes in CAR T cells is …