Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …

Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C,
cause Emery–Dreifuss muscular dystrophy, congenital muscular dystrophy and other …

The mechanical properties of the cell nucleus are increasingly recognized as critical in many
biological processes. The deformability of the nucleus determines the ability of immune and …

The nuclei of multinucleated skeletal muscles experience substantial external force during
development and muscle contraction. Protection from such forces is partly provided by lamins, …

Cells respond to mechanical stimulation by activation of specific signaling pathways and
genes that allow the cell to adapt to its dynamic physical environment. How cells sense the …

Lamins A/C are nuclear intermediate filament proteins that are involved in diverse cellular
mechanical and biochemical functions. Here, we report that recognition of Lamins A/C by a …

Lamins A/C are nuclear intermediate filament proteins that are involved in diverse cellular
mechanical and biochemical functions. Here, we report that recognition of Lamins A/C by a …

Mutations in the human LMNA gene, which encodes the nuclear envelope proteins lamins
A and C, cause Emery-Dreifuss muscular dystrophy (EDMD), congenital muscular dystrophy, …

… While in Rochester, Greg became interested in applying his … Greg’s research has contributed
mechanistic insights into how … After his doctoral studies, Greg plans to pursue a career in …

Mechanically-induced nuclear damage and increased p53 signaling lead to myofiber
dysfunction in skeletal muscle laminopathies - Archive ouverte HAL Accéder directement au …