User profiles for Gregory R. Sliwoski
 | Gregory SliwoskiVanderbilt University Verified email at vanderbilt.edu Cited by 2681 |
An Acquired HER2 T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant–Driven Breast Cancer
…, JP Koch, GR Sliwoski, R Nagy, R Lanman… - Cancer discovery, 2017 - AACR
We report a HER2 T798I gatekeeper mutation in a patient with HER2 L869R -mutant breast
cancer with acquired resistance to neratinib. Laboratory studies suggested that HER2 …
cancer with acquired resistance to neratinib. Laboratory studies suggested that HER2 …
[HTML][HTML] Clozapine interaction with phosphatidyl inositol 3-kinase (PI3K)/insulin-signaling pathway in Caenorhabditis elegans
R Karmacharya, GR Sliwoski, MY Lundy… - …, 2009 - nature.com
Clozapine has superior and unique effects as an antipsychotic agent, but the mediators of
these effects are not known. We studied behavioral and developmental effects of clozapine in …
these effects are not known. We studied behavioral and developmental effects of clozapine in …
[HTML][HTML] Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket
X Pedragosa-Badia, GR Sliwoski, ED Nguyen… - Journal of Biological …, 2014 - ASBMB
Structural characterization of the human Y 4 receptor (hY 4 R) interaction with human pancreatic
polypeptide (hPP) is crucial, not only for understanding its biological function but also …
polypeptide (hPP) is crucial, not only for understanding its biological function but also …
[HTML][HTML] A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target
T Saur, SE DeMarco, A Ortiz, GR Sliwoski, L Hao… - PLoS …, 2013 - journals.plos.org
We report a genome-wide RNA interference (RNAi) screen for Suppressors of Clozapine-induced
Larval Arrest (scla genes) in Caenorhabditis elegans, the first genetic suppressor …
Larval Arrest (scla genes) in Caenorhabditis elegans, the first genetic suppressor …
[HTML][HTML] PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection
Germline disease-causing variants are generally more spatially clustered in protein 3-dimensional
structures than benign variants. Motivated by this tendency, we develop a fast and …
structures than benign variants. Motivated by this tendency, we develop a fast and …
The Relevance ofCaenorhabditis elegansGenetics for Understanding Human Psychiatric Disease
X Wang, GR Sliwoski, EA Buttner - Harvard Review of Psychiatry, 2011 - journals.lww.com
How mutations in human genes cause disease remains unclear in most cases. If we can
understand the molecular mechanisms through which specific genes cause or increase the risk …
understand the molecular mechanisms through which specific genes cause or increase the risk …
The impact of natural selection on the evolution and function of placentally expressed galectins
ZA Ely, JM Moon, GR Sliwoski… - Genome Biology and …, 2019 - academic.oup.com
Immunity genes have repeatedly experienced natural selection during mammalian evolution.
Galectins are carbohydrate-binding proteins that regulate diverse immune responses, …
Galectins are carbohydrate-binding proteins that regulate diverse immune responses, …
The impact of natural selection on the evolution and function of placentally expressed galectins
ZA Ely, JM Moon, GR Sliwoski, AK Sangha, XX Shen… - bioRxiv, 2018 - biorxiv.org
Immunity genes have repeatedly experienced natural selection during mammalian evolution.
Galectins are carbohydrate-binding proteins that regulate diverse immune responses, …
Galectins are carbohydrate-binding proteins that regulate diverse immune responses, …
[PDF][PDF] Pancreatic Polypeptide is Recognized by
…, D Lindner, JX Pedragosa-Badia, GR Sliwoski - 2013 - Citeseer
To whom the correspondence should be addressed: Annette G. Beck-Sickinger, Institute of
Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, Universität Leipzig, …
Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, Universität Leipzig, …
Correction: An Acquired HER2T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant–Driven Breast Cancer
…, JP Koch, GR Sliwoski, R Nagy, R Lanman… - Cancer discovery, 2019 - AACR
In the original version of this article (1), the stated disclosure of the author Carlos L. Arteaga
is incorrect. The error has been corrected in the latest online HTML and PDF versions of the …
is incorrect. The error has been corrected in the latest online HTML and PDF versions of the …