Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium

GS Canfield, A Chatterjee, J Espinosa… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Enterococcus faecium , a commensal of the human intestine, has emerged as a hospital-adapted,
multidrug-resistant (MDR) pathogen. Bacteriophages (phages), natural predators of …

[HTML][HTML] Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant Enterococcus faecium with Preserved Phage …

…, B Biswas, M Wilson, MV Deschenes, GS Canfield… - Antibiotics, 2022 - mdpi.com
Multidrug-resistant (MDR) Enterococcus faecium is a challenging nosocomial pathogen known
to colonize medical device surfaces and form biofilms. Bacterio (phages) may constitute …

Bacteriophage-antibiotic combinations for Enterococcus faecium with varying bacteriophage and daptomycin susceptibilities

…, S Morales, SM Lehman, GS Canfield… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate
novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are …

[HTML][HTML] Evaluation of Bacteriophage-Antibiotic Combination Therapy for Biofilm-Embedded MDR Enterococcus faecium

…, T Morrisette, K Stamper, DJ Holger, GS Canfield… - Antibiotics, 2022 - mdpi.com
Multidrug-resistant (MDR) Enterococcus faecium is a challenging pathogen known to cause
biofilm-mediated infections with limited effective therapeutic options. Lytic bacteriophages …

Evolution in fast forward: a potential role for mutators in accelerating Staphylococcus aureus pathoadaptation

GS Canfield, JM Schwingel, MH Foley… - Journal of …, 2013 - Am Soc Microbiol
Pathogen evolution and subsequent phenotypic heterogeneity during chronic infection are
proposed to enhance Staphylococcus aureus survival during human infection. We tested this …

Increased cryptococcal meningitis mortality among HIV negative, non-transplant patients: a single US center cohort study

…, D Chastain, S Mann, GS Canfield… - Therapeutic …, 2020 - journals.sagepub.com
Cryptococcal meningitis (CM) is an opportunistic fungal infection associated with human
immunodeficiency virus (HIV) and other forms of immunosuppression. We lack a clear …

Potential Influence of Staphylococcus aureus Clonal Complex 30 Genotype and Transcriptome on Hematogenous Infections

…, JR Myers, KL Vore, GS Canfield… - Open forum …, 2015 - academic.oup.com
Background. The contemporary Staphylococcus aureus clonal complex (CC) 30 lineage is
associated with complicated infections, including endocarditis and osteomyelitis. This lineage …

Molecular mechanisms of enterococcal-bacteriophage interactions and implications for human health

GS Canfield, BA Duerkop - Current opinion in microbiology, 2020 - Elsevier
… Author links open overlay panel Gregory S Canfield 1 2 , Breck A Duerkop 2 … Comparison
of Lysin CF-301 (Exebacase) activity against S. aureus isolates from bacteremic patients …

Evaluation of bacteriophage cocktails alone and in combination with daptomycin against daptomycin-nonsusceptible Enterococcus faecium

T Morrisette, KL Lev, GS Canfield… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Enterococcus faecium is a significant multidrug-resistant pathogen. Bacteriophage cocktails
are being proposed to complement antibiotic therapy. After a screen of 8 E. faecium strains …

Bacteriophage and antibiotic combination therapy for recurrent Enterococcus faecium bacteremia

…, E Dembinski, MR Mangalea, G Arya, GS Canfield… - Mbio, 2024 - Am Soc Microbiol
Enterococcus faecium is a member of the human gastrointestinal (GI) microbiota but can
also cause invasive infections, especially in immunocompromised hosts. Enterococci display …