Patterning of the dorsal-ventral axis in the early Drosophila embryo depends on the nuclear
distribution of the Dorsal transcription factor. Using live two-photon light-sheet microscopy, …

The epidermal growth factor receptor (EGFR) has critical functions in development and in
many human cancers 1 , 2 , 3 . During development, the spatial extent of EGFR signalling is …

A gradient of Dorsal activity patterns the dorsoventral (DV) axis of the early Drosophila
melanogaster embryo by controlling the expression of genes that delineate presumptive …

Migration is a complex, dynamic process that has largely been studied using qualitative or
static approaches. As technology has improved, we can now take quantitative approaches …

The NF-κB-related transcription factor, Dorsal, forms a nuclear concentration gradient in the
early Drosophila embryo, patterning the dorsal-ventral (DV) axis to specify mesoderm, …

Pattern formation in developing organisms can be regulated at a variety of levels, from gene
sequence to anatomy. At this level of complexity, mechanistic models of development …

Quantitative information about the distribution of morphogens is crucial for understanding
their effects on cell-fate determination, yet it is difficult to obtain through direct measurements. …

Motivation Mathematical models in systems biology help generate hypotheses, guide
experimental design, and infer the dynamics of gene regulatory networks. These models are …

Background Regulation of gene expression is of paramount importance in all living systems.
In the past two decades, it has been discovered that certain motifs, such as the feedforward …

The transcription factor NF-κB plays an important role in the immune system, apoptosis and
inflammation. Dorsal, a Drosophila homolog of NF-κB, patterns the dorsal-ventral axis in the …