Cancer-associated fibroblasts (CAFs) play a role in response to cancer treatment and patient
prognosis. CAFs show phenotypic and functional heterogeneity and differ widely in tumors …

Integrative analysis of multi-omics layers at single cell level is critical for accurate dissection
of cell-to-cell variation within certain cell populations. Here we report scCAT-seq, a …

Single cell genomics is a rapidly growing field with many new techniques emerging in the past
few years. However, few bioinformatics tools specific for single cell genomics analysis are …

Background Single-cell resequencing (SCRS) provides many biomedical advances in
variations detection at the single-cell level, but it currently relies on whole genome amplification (…

Diffuse large B cell lymphoma (DLBCL) is one of the most common yet aggressive types of
B cell lymphoma and remains incurable in 40% of patients. Herein, we profile the …

Background Cancers arise through an evolutionary process in which cell populations are
subjected to selection; however, to date, the process of bladder cancer, which is one of the …

Previous studies have demonstrated focal but limited molecular similarities between circulating
tumor cells (CTCs) and biopsies using isolated genetic assays. We hypothesized that …

With the increase of running speed, high-speed trains have higher requirement for aerodynamic
shape. The pursuit of excellent performance and beautiful aerodynamic shape tends to …

Background Little is known on the tumor microenvironment (TME) response after neoadjuvant
chemotherapy (NACT) in gastric cancer on the molecular level. Methods Here, we profiled …

Background Viral infection causes multiple forms of human cancer, and HPV infection is the
primary factor in cervical carcinomas. Recent single-cell RNA-seq studies highlight the …