Metabolic associated fatty liver disease (MAFLD) encompasses a broad spectrum of hepatic
disorders, including steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis. We …

Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of
immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. …

Solute carrier family 27 member 5 (SLC27A5/FATP5) is involved in fatty acid transport and
bile acid metabolism; however, little is known about its role in human diseases. Here, we first …

Coronavirus disease 2019 (COVID-19) caused by the emerging severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has set off a global pandemic. There is an urgent …

After the pandemic of COVID-19, neutralizing antibodies (NAbs) against SARS-CoV-2 have
been developed for the prophylactic and therapeutic purposes. However, few methodologies …

Gluconeogenesis, generates glucose from small carbohydrate substrates, and drives the
metabolic flux in parallel but opposite to glycolysis. The cytoplasmic isoform of …

Liver hepatocellular carcinoma (LIHC) is the second leading cause of cancer mortality
worldwide. Although cancer driver genes identified so far have been considered to be saturated …

Biosensors have emerged as ideal analytical devices for various bio-applications owing to
their low cost, convenience, and portability, which offer great potential for improving global …

Vesicle Protein Sorting 35 (VPS35) is a novel oncogene that promotes tumor growth through
the PI3K/AKT signaling in hepatocellular carcinoma (HCC). However, the role of VPS35 in …

Liver cancer stem cells were found to rely on glycolysis as the preferred metabolic program.
Phosphoenolpyruvate carboxylase 1 (PCK1), a gluconeogenic metabolic enzyme, is down-…