User profiles for Guilherme C.P. Innocentini
Guilherme InnocentiniIME-USP Verified email at ime.usp.br Cited by 510 |
Self-regulating gene: an exact solution
An exact steady-state solution of the stochastic equations governing the behavior of a gene
regulated by a self-generated proteomic atmosphere is presented. The solutions depend on …
regulated by a self-generated proteomic atmosphere is presented. The solutions depend on …
Exact time-dependent solutions for a self-regulating gene
AF Ramos, GCP Innocentini, JEM Hornos - Physical Review E, 2011 - APS
The exact time-dependent solution for the stochastic equations governing the behavior of a
binary self-regulating gene is presented. Using the generating function technique to …
binary self-regulating gene is presented. Using the generating function technique to …
Modeling stochastic gene expression under repression
GCP Innocentini, JEM Hornos - Journal of Mathematical Biology, 2007 - Springer
Intrinsic transcriptional noise induced by operator fluctuations is investigated with a simple
spin-like stochastic model. The effects of transcriptional fluctuations in protein synthesis are …
spin-like stochastic model. The effects of transcriptional fluctuations in protein synthesis are …
Protein synthesis driven by dynamical stochastic transcription
In this manuscript, we propose a mathematical framework to couple transcription and
translation in which mRNA production is described by a set of master equations, while the …
translation in which mRNA production is described by a set of master equations, while the …
Relating network rigidity, time scale hierarchies, and expression noise in gene networks
O Radulescu, GCP Innocentini, JEM Hornos - Physical Review E, 2012 - APS
Fluctuation-dissipation theorems can be used to predict characteristics of noise from
characteristics of the macroscopic response of a system. In the case of gene networks, feedback …
characteristics of the macroscopic response of a system. In the case of gene networks, feedback …
[HTML][HTML] Time dependent stochastic mRNA and protein synthesis in piecewise-deterministic models of gene networks
GCP Innocentini, A Hodgkinson, O Radulescu - Frontiers in Physics, 2018 - frontiersin.org
We discuss piecewise-deterministic approximations of gene networks dynamics. These
approximations capture in a simple way the stochasticity of gene expression and the …
approximations capture in a simple way the stochasticity of gene expression and the …
[HTML][HTML] Comment on “Steady-state fluctuations of a genetic feedback loop: An exact solution”[J. Chem. Phys. 137, 035104 (2012)]
GCP Innocentini, AF Ramos… - The Journal of chemical …, 2015 - pubs.aip.org
The comment presents the complete steady state solution of the model introduced on”
Steady-state fluctuations of a genetic feedback loop: An exact solution”[Grima et al. J. Chem. Phys. …
Steady-state fluctuations of a genetic feedback loop: An exact solution”[Grima et al. J. Chem. Phys. …
Analytic framework for a stochastic binary biological switch
We propose and solve analytically a stochastic model for the dynamics of a binary biological
switch, defined as a DNA unit with two mutually exclusive configurations, each one …
switch, defined as a DNA unit with two mutually exclusive configurations, each one …
Effective computational methods for hybrid stochastic gene networks
GCP Innocentini, F Antoneli, A Hodgkinson… - … Methods in Systems …, 2019 - Springer
At the scale of the individual cell, protein production is a stochastic process with multiple time
scales, combining quick and slow random steps with discontinuous and smooth variation. …
scales, combining quick and slow random steps with discontinuous and smooth variation. …
Push-forward method for piecewise deterministic biochemical simulations
GCP Innocentini, A Hodgkinson, F Antoneli… - Theoretical Computer …, 2021 - Elsevier
A biochemical network can be simulated by a set of ordinary differential equations (ODE)
under well-stirred reactor conditions, for large numbers of molecules, and frequent reactions. …
under well-stirred reactor conditions, for large numbers of molecules, and frequent reactions. …