Since the first high-resolution structure of the nucleosome was reported in 1997, the available
information on chromatin structure has increased very rapidly. Here, we review insights …

The chromatin remodeler ALC1 is recruited to and activated by DNA damage-induced poly (ADP-ribose)(PAR)
chains deposited by PARP1/PARP2/HPF1 upon detection of DNA lesions…

La mortalité des enfants était en baisse en Zambie, de l’indépendance en 1964 jusqu’en
1975, grâce aux politiques sociales et sanitaires généreuses alimentées par le revenu du …

Poly(ADP-ribose) Polymerase 2 (PARP2) is one of three DNA-dependent PARPs involved
in the detection of DNA damage. Upon binding to DNA double-strand breaks, PARP2 uses …

Upon DNA damage, the ALC1/CHD1L nucleosome remodeling enzyme (remodeler) is
activated by binding to poly(ADP-ribose). How activated ALC1 recognizes the nucleosome, as …

Document recommendation systems for locating relevant literature have mostly relied on
methods developed a decade ago. This is largely due to the lack of a large offline gold-…

Telomere integrity is essential to maintain genome stability, and telomeric dysfunctions are
associated with cancer and aging pathologies. In human, the shelterin complex binds …

The nucleosome presents a formidable barrier to DNA-templated transcription by the RNA
polymerase II machinery. Overcoming this transcriptional barrier in a locus-specific manner …

One of the most important challenges in cryogenic electron microscopy (cryo-EM) is the
substantial number of samples that exhibit preferred orientations, which leads to an uneven …

Les télomères sont les extrémités des chromosomes linéaires des eucaryotes.Ils sont
constitués de répétitions en tandem d'un motif court riche enguanine, et liés par des protéines …