A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …

While long-read sequencing allows for the complete assembly of bacterial genomes, long-read
assemblies contain a variety of errors. Here, we present Trycycler, a tool which produces …

Human genetic variation affects the gut microbiota through a complex combination of
environmental and host factors. Here we characterize genetic variations associated with microbial …

Genome-wide association studies have the potential to identify causal genetic factors
underlying important phenotypes but have rarely been performed in bacteria. We present an …

The human microbiome has been increasingly recognized as having potential use for
disease prediction. Predicting the risk, progression, and severity of diseases holds promise to …

The opportunistic pathogens Staphylococcus aureus and Staphylococcus epidermidis
represent major causes of severe nosocomial infection, and are associated with high levels of …

Chickens are the most common birds on Earth and colibacillosis is among the most common
diseases affecting them. This major threat to animal welfare and safe sustainable food …

Homologous recombination between bacterial strains is theoretically capable of preventing
the separation of daughter clusters, and producing cohesive clouds of genotypes in …

The increasing availability of hundreds of whole bacterial genomes provides opportunities
for enhanced understanding of the genes and alleles responsible for clinically important …

Hybridization between distantly related organisms can facilitate rapid adaptation to novel
environments, but is potentially constrained by epistatic fitness interactions among cell …