Lung function in early adulthood and health in later life: a transgenerational cohort analysis
Background Early life events can affect health in later life. We hypothesised that low lung
function (FEV 1 <80% predicted) in early adulthood (25–40 years) is associated with higher …
function (FEV 1 <80% predicted) in early adulthood (25–40 years) is associated with higher …
Network analysis of lung transcriptomics reveals a distinct B-cell signature in emphysema
…, T Casserras, A López-Giraldo, G Noell… - American journal of …, 2016 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow
limitation caused by a combination of airways disease (bronchiolitis) and parenchymal …
limitation caused by a combination of airways disease (bronchiolitis) and parenchymal …
[HTML][HTML] Multi-level immune response network in mild-moderate Chronic Obstructive Pulmonary Disease (COPD)
T Cruz, A López-Giraldo, G Noell… - Respiratory …, 2019 - Springer
Background Chronic Obstructive Pulmonary Disease (COPD) is associated with an abnormal
pulmonary and systemic immune response to tobacco smoking. Yet, how do immune cells …
pulmonary and systemic immune response to tobacco smoking. Yet, how do immune cells …
Multi-level differential network analysis of COPD exacerbations
Patients with chronic obstructive pulmonary disease (COPD) often suffer episodes of
exacerbation (ECOPD) that impact negatively the course of their disease. ECOPD are …
exacerbation (ECOPD) that impact negatively the course of their disease. ECOPD are …
From systems biology to P4 medicine: applications in respiratory medicine
Human health and disease are emergent properties of a complex, nonlinear, dynamic
multilevel biological system: the human body. Systems biology is a comprehensive research …
multilevel biological system: the human body. Systems biology is a comprehensive research …
[HTML][HTML] Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD
X Li, G Noell, T Tabib, AD Gregory, HE Trejo Bittar… - Respiratory …, 2021 - Springer
Background Whole lung tissue transcriptomic profiling studies in chronic obstructive
pulmonary disease (COPD) have led to the identification of several genes associated with the …
pulmonary disease (COPD) have led to the identification of several genes associated with the …
[HTML][HTML] Lung DNA methylation in chronic obstructive pulmonary disease: relationship with smoking status and airflow limitation severity
S Casas-Recasens, G Noell, N Mendoza… - American Journal of …, 2021 - atsjournals.org
Methods Lung tissue was obtained from individuals undergoing thoracic surgery because of
lung cancer or lung transplant. Participants (Table 1) were categorized as never-smokers …
lung cancer or lung transplant. Participants (Table 1) were categorized as never-smokers …
[PDF][PDF] Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells
Perturbing expression is a powerful way to understand the role of individual genes, but can
be challenging in important models. CRISPR-Cas screens in human induced pluripotent …
be challenging in important models. CRISPR-Cas screens in human induced pluripotent …
Minimized double guide RNA libraries enable scale-limited CRISPR/Cas9 screens
Genetic screens based on CRISPR/Cas technology are a powerful tool for understanding
cellular phenotypes. However, the coverage and replicate requirements result in large …
cellular phenotypes. However, the coverage and replicate requirements result in large …
[HTML][HTML] Distribution, temporal stability and association with all-cause mortality of the 2017 GOLD groups in the ECLIPSE cohort
R Faner, G Noell, JR Badia, A López-Giraldo… - Respiratory …, 2018 - Elsevier
Background In 2017, the Global Initiative for Chronic Obstructive Lung Disease (GOLD)
proposed a new classification of patients with chronic obstructive pulmonary disease (COPD). …
proposed a new classification of patients with chronic obstructive pulmonary disease (COPD). …