The serum- and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and
under genomic control by cell stress (including cell shrinkage) and hormones (including gluco- …

The present brief review highlights the putative role of the serum‐ and glucocorticoid‐inducible‐kinase‐1
(SGK1) in the regulation of neuronal function. SGK1 is genomically …

K V 7 voltage-gated potassium channels, encoded by the KCNQ gene family, have caught
increasing interest of the scientific community for their important physiological roles, which are …

We have isolated KCNQ5, a novel human member of the KCNQ potassium channel gene
family that is differentially expressed in subregions of the brain and in skeletal muscle. When …

Retigabine (RTG) is an anticonvulsant drug with a novel mechanism of action. It activates
neuronal KCNQ-type K + channels by inducing a large hyperpolarizing shift of steady-state …

Three-dimensional (3D) culture systems have fueled hopes to bring about the next
generation of more physiologically relevant high-throughput screens (HTS). However, current …

Glucocorticoid excess predisposes to the development of diabetes, at least in part through
impairment of insulin secretion. The underlying mechanism has remained elusive. We show …

Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening
cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of …

Unintended block of HERG K + channels is a side effect of many common medications and
is the most common cause of acquired long QT syndrome associated with increased risk of …

The scaling relationship between the size of an appendage or organ and that of the body as
a whole is tightly regulated during animal development. If a structure grows at a different …