[HTML][HTML] Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells

…, M Lee, D Lee, M Pretorius, B Radford, G Makkar… - Scientific Reports, 2021 - nature.com
Pancreatic islets adapt to insulin resistance of pregnancy by up regulating β-cell mass and
increasing insulin secretion. Previously, using a transgenic mouse with global, heterozygous …

[HTML][HTML] Comparison of two colloidal silica-based sperm separation media with a non–silica-based medium

G Makkar, HY Ng, SB Yeung, PC Ho - Fertility and sterility, 1999 - Elsevier
Objective: To study and compare the effects of three sperm separation media, two silica-based
(Percoll; Pharmacia Biotech AB, Uppsala, Sweden, and Isolate; Irvine Scientific, Santa …

Reduced Expression of Interleukin-11 and Interleukin-6 in the Periimplantation Endometrium of Excessive Ovarian Responders during in Vitro Fertilization Treatment

G Makkar, EHY Ng, WSB Yeung… - The Journal of Clinical …, 2006 - academic.oup.com
Context: Impaired implantation in assisted reproduction cycles with high serum estradiol (E2)
concentrations may be related to abnormal endometrial functions. Objective: The in vivo …

The significance of the ionophore‐challenged acrosome reaction in the prediction of successful outcome of controlled ovarian stimulation and intrauterine …

G Makkar, EHY Ng, WSB Yeung, PC Ho - Human Reproduction, 2003 - academic.oup.com
BACKGROUND: This prospective study compared the acrosome reaction following
ionophore challenge (ARIC) versus conventional sperm parameters and sperm velocities in …

A comparative study of raw and prepared semen samples from two consecutive days.

G Makkar, EH Ng, WS Yeung, PC Ho - The Journal of reproductive …, 2001 - europepmc.org
Objective To study and compare raw and prepared semen samples from two consecutive
days by conventional sperm parameters, various motility characteristics of spermatozoa …

Lrrc55 is a novel prosurvival factor in pancreatic islets

G Makkar, V Shrivastava, B Hlavay… - American Journal …, 2019 - journals.physiology.org
Pancreatic islets adapt to the increase in insulin demand during pregnancy by upregulating
β-cell number, insulin synthesis, and secretion. These changes require prolactin receptor (…

A randomized comparison of three insemination methods in an artificial insemination program using husbands' semen.

EH Ng, G Makkar, WS Yeung, PC Ho - The Journal of reproductive …, 2003 - europepmc.org
Objective To compare pregnancy rates with single intrauterine insemination (SIUI), double
intrauterine insemination (DIUI) and fallopian tube sperm perfusion (FSP). Study design …

[HTML][HTML] Excessive ovarian response is associated with increased expression of interleukin-2 in the periimplantation endometrium

G Makkar, EHY Ng, WSB Yeung, PC Ho - Fertility and sterility, 2009 - Elsevier
OBJECTIVE: To evaluate and compare in vivo expression of T helper type 1 (Th1) cytokines
in the peri-implantation endometrium of infertile patients between natural and stimulated …

Regulation of islet function and gene expression by prolactin during pregnancy

V Shrivastava, M Lee, M Pretorius, G Makkar, C Huang - bioRxiv, 2019 - biorxiv.org
Pancreatic islets adapt to insulin resistance of pregnancy by up regulating β-cell proliferation
and increase insulin secretion. Previously, we found that prolactin receptor (Prlr) signaling …

[PDF][PDF] Novel signaling target of prolactin receptor in pancreatic β-cells

G Makkar - 2018 - prism.ucalgary.ca
Prolactin receptor mediated β-cell mass adaptation is essential for glucose homeostasis
during pregnancy. In this study, we have identified Lrrc55 as a novel downstream target of …