Gene expression is a multistep process that involves the transcription, translation and turnover
of messenger RNAs and proteins. Although it is one of the most fundamental processes of …

Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely
unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-)malignant cells 1 , 2 . Key signalling components of the senescence …

The yeast protein Rad23 belongs to a diverse family of proteins that contain an amino-terminal
ubiquitin-like (UBL) domain. This domain mediates the binding of Rad23 to proteasomes, …

Ubiquitin is ligated to L28, a component of the large ribosomal subunit, to form the most
abundant ubiquitin–protein conjugate in S. cerevisiae. The human ortholog of L28 is also …

Current methods for system‐wide gene expression analysis detect changes in mRNA
abundance, but neglect regulation at the level of translation. Pulse labeling with stable isotopes …

Cellular circular RNAs (circRNAs) are generated by head-to-tail splicing and are present in
all multicellular organisms studied so far. Recently, circRNAs have emerged as a large class …

As part of the genotoxic stress response, cells activate the transcription factor NF-κB. The
DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and the kinase ataxia …

Aging is characterized by the accumulation of damaged cellular macromolecules caused by
declining repair and elimination pathways. An integral component employed by cells to …

Mark Biggin of the Lawrence Berkeley National Laboratory contacted us, noting that our
mass-spectrometry-based protein copy number estimates are lower than several literature-…