Introduction Embryogenesis is thought to be directed by a small number of signaling pathways
with most if not all embryonic signals having been identified. However, the molecular …

Large-scale genomics and computational approaches have identified thousands of putative
long non-coding RNAs (lncRNAs). It has been controversial, however, as to what fraction of …

The unique reactivity of two sortase enzymes, SrtA staph from Staphylococcus aureus and
SrtA strep from Streptococcus pyogenes, is exploited for site-specific labeling of a single …

SF3B1 is the most commonly mutated RNA splicing factor in cancer 1 , 2 , 3 – 4 , but the
mechanisms by which SF3B1 mutations promote malignancy are poorly understood. Here we …

Upstream open reading frames (uORFs) are ubiquitous repressive genetic elements in vertebrate
mRNAs. While much is known about the regulation of individual genes by their uORFs, …

Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome,
which removes >99% of introns, and the minor spliceosome, which removes rare, …

Folding and stability are parameters that control protein behavior. The possibility of conferring
additional stability on proteins has implications for their use in vivo and for their structural …

The stability of mRNAs is regulated by signals within their sequences, but a systematic and
predictive understanding of the underlying sequence rules remains elusive. Here we …

Advances in cancer immunotherapies make it critical to identify genes that modulate antigen
presentation and tumor-immune interactions. We report that DUX4, an early embryonic …

Short H2A (sH2A) histone variants are primarily expressed in the testes of placental mammals.
Their incorporation into chromatin is associated with nucleosome destabilization and …