Background Extensive-stage small-cell lung cancer (ES-SCLC) is associated with poor
prognosis and treatment options are scarce. Immunotherapy has shown robust clinical activity in …

Purpose: To evaluate the efficacy and safety of RC48-ADC, a novel humanized anti-HER2
antibody conjugated with monomethyl auristatin E, in patients with HER2 + locally advanced …

Background Current treatment options for human epidermal growth factor receptor 2 (HER2)‐overexpressing
gastric cancer at third‐line have shown limited clinical benefit. Further, …

PURPOSE Patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC)
have poor prognosis. For these patients, treatment options are limited after first-line …

Introduction Blocking vascular endothelial growth factor pathway can enhance the efficacy of
EGFR tyrosine kinase inhibitors in EGFR-mutant NSCLC. ACTIVE is the first phase 3 study …

Background VTE has emerged as a major public health problem. However, data on VTE
burden in China are seldom reported. Methods This study collected data on patients with a …

Background Lung adenocarcinoma (LUAD) is a common type of lung cancer with a high risk
of metastasis, but the exact molecular mechanisms of metastasis are not yet understood. …

425126 Background: Adjuvant and neoadjuvant immunotherapy have been approved by US
FDA to treat early-stage NSCLC. However, the optimal neoadjuvant and adjuvant treatment…

Background Zuojinwan (ZJW), a classic herbal formula, has been extensively used to treat
gastric symptoms in clinical practice in China for centuries. However, the pharmacological …

Molecular mechanisms underlying the cancer stroma in metastasis need further exploration.
Here, we discovered that cancer-associated fibroblasts (CAFs) produced high levels of IL-…