Retinal levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived
factor (PEDF), an angiogenic inhibitor, were measured and correlated with the ischemia-…

Pigment epithelium‐derived factor (PEDF) is a potent angiogenic inhibitor. Reduced PEDF
levels are associated with diabetic retinopathy. However, the mechanism for the protective …

It has been shown that the balance between vascular endothelial growth factor (VEGF), a
major angiogenic stimulator, and pigment epithelium-derived factor (PEDF), a potent …

Although Wnt signaling is known to mediate multiple biological and pathological processes,
its association with diabetic retinopathy (DR) has not been established. Here we show that …

Wnt signaling is known to regulate multiple processes including angiogenesis, inflammation,
and fibrosis. Here, we identified a novel inhibitor of the Wnt pathway, pigment epithelium-…

Purpose. Pterygia are histologically composed of proliferating fibrovascular tissue. This study
compared expression levels of an angiogenic inhibitor, pigment epithelium-derived factor (…

Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular
complication of diabetes. The current study revealed that plasma levels of pigment epithelium–…

Gastric cancer and breast cancer have a clear tendency toward metastasis and invasion to
the microenvironment predominantly composed of adipocytes. Oleic acid is an abundant …

We have previously shown that intravitreal injection of plasminogen kringle 5 (K5), a potent
angiogenic inhibitor, inhibits ischemia-induced retinal neovascularization in a rat model. …

The underlying molecular mechanism whereby hyperglycemia causes endothelial cell
apoptosis is not well understood. This study aims to elucidate the role of survival factor VEGF …