Antibodies targeting the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
present a promising approach to combat the coronavirus disease 2019 (COVID…

A diverse T cell repertoire is a critical component of the adaptive immune system, providing
protection against invading pathogens and neoplastic changes, relying on the recognition of …

Novel developmental programs often evolve via cooption of existing genetic networks. To
understand this process, we explored cooption of the TAS3 tasiRNA pathway in the moss …

An urgent global quest for effective therapies to prevent and treat coronavirus disease 2019
(COVID-19) is ongoing. We previously described REGN-COV2, a cocktail of two potent …

Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …

How should one quantify the strength of association between two random variables without
bias for relationships of a specific form? Despite its conceptual simplicity, this notion of …

Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been
associated with ageing and adverse health outcomes 1 , 2 , 3 , 4 – 5 . Here we use exome …

Monoclonal antibodies against SARS-CoV-2 are a clinically validated therapeutic option
against COVID-19. Because rapidly emerging virus mutants are becoming the next major …

In an age of increasingly large data sets, investigators in many different disciplines have
turned to clustering as a tool for data analysis and exploration. Existing clustering methods, …

We present Ginkgo ( http://qb.cshl.edu/ginkgo ), a user-friendly, open-source web platform for
the analysis of single-cell copy-number variations (CNVs). Ginkgo automatically constructs …