Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T-cell
acute lymphoblastic leukemia (T-ALL), highlighting the Notch signaling pathway as a …

NOTCH1 is a well-established lineage specifier for T cells and among the most frequently
mutated genes throughout all subclasses of T cell acute lymphoblastic leukemia (T-ALL). How …

Expanded CAG/CTG repeats underlie 13 neurological disorders, including myotonic
dystrophy type 1 (DM1) and Huntington’s disease (HD). Upon expansion, disease loci acquire …

MAGI1 acts as a tumor suppressor in estrogen receptor-positive (ER + ) breast cancer (BC),
and its loss correlates with a more aggressive phenotype. To identify the pathways and …

We present µLAS, a lab-on-chip system that concentrates, separates, and detects DNA
fragments in a single module. µLAS speeds up DNA size analysis in minutes using femtomolar …

The natural restoration of soils polluted by aromatic hydrocarbons such as benzene, toluene,
ethylbenzene and m- and p-xylene (BTEX) may be accelerated by inoculation of specific …

Expanded CAG/CTG repeat disorders affect over 1 in 2500 individuals worldwide. Potential
therapeutic avenues include gene silencing and modulation of repeat instability. However, …

Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T
cell acute lymphoblastic leukemia (T-ALL), making the Notch signaling pathway a promising …

Background New onsets of chronic urticaria (CU) have been reported after repeated
immunizations, mainly with the Moderna mRNA-1273 vaccine (Spikevax) Objective This study aims …

Background Moderate altitudes carry physiological and metabolic changes that can
dampen exercise performance. Fortunately, these changes can be modulated by an optimal …