The treatment of Alzheimer's disease and many other brain-related disorders is limited because
of the presence of the blood–brain barrier, which highly regulate the crossing of drugs. …

Huntingtin regulates post-Golgi trafficking of secreted proteins. Here, we studied the mechanism
by which mutant huntingtin impairs this process. Colocalization studies and Western …

Secretion and endocytosis are highly dynamic processes that are sensitive to external
stimuli. Thus, in multicellular organisms, different cell types utilize specialised pathways of …

The blood–brain barrier (BBB) is a formidable physical and enzymatic barrier that tightly
controls the passage of molecules from the blood to the brain. In fact, less than 2 % of all …

Objective— Marfan’s syndrome is characterized by the formation of ascending aortic
aneurysms resulting from altered assembly of extracellular matrix microfibrils and chronic tissue …

Reactive oxygen and nitrogen species are produced in a wide range of physiological reactions
that, at low concentrations, play essential roles in living organisms. There is a delicate …

Transforming growth factor‐beta (TGF‐β) is an important regulatory suppressor factor in
hepatocytes. However, liver tumor cells develop mechanisms to overcome its suppressor effects …

Actin is involved in the organization of the Golgi complex and Golgi-to-ER protein transport
in mammalian cells. Little, however, is known about the regulation of the Golgi-associated …

The organization and function of the Golgi complex was studied in normal rat kidney cells
following disruption of the actin cytoskeleton induced by cytochalasin D. In cells treated with …

Erythrocytes are flexible cells specialized in the systemic transport of oxygen in vertebrates.
This physiological function is connected to their outstanding ability to deform in passing …