Sexual dimorphism at the level of MDSC subset prevalence, localization, and gene-expression
profile constitutes a therapeutic opportunity. Our results indicate that chemotherapy can …

The application of tumor immunotherapy to glioblastoma (GBM) is limited by an unprecedented
degree of immune suppression due to factors that include high numbers of immune …

BACKGROUND Myeloid-derived suppressor cells (MDSCs) are elevated in the circulation
of patients with glioblastoma (GBM), present in tumor tissue, and associated with poor …

Glioblastoma (GBM) remains among the deadliest of human malignancies, and the
emergence of the cancer stem cell (CSC) phenotype represents a major challenge to durable …

Cancer stem cells (CSC) drive tumor growth in many cancers including GBM. We identified
a novel sheddase, ADAMDEC1, which initiates an FGF autocrine loop to promote stemness …

Background Most partial nephrectomies (PNs) are performed with hilar occlusion to reduce
blood loss and optimize visualization. However, the histologic status of the preserved renal …

Prostate cancer and breast cancer are sex-steroid–dependent diseases that are driven in
major part by gonadal sex steroids. Testosterone (T) is converted to 5α-dihydrotestosterone, …

Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors driven by populations
of cancer stem cells (CSCs). However, few molecular mechanisms critical for CSC …

Background Recent publications have reported an association between increased renal
cancer-specific mortality (CSM) and reduced renal function “below safety limits,” and advocated …

Accurate prediction of new baseline GFR (NBGFR) after radical nephrectomy (RN) can
inform clinical management and patient counseling whenever RN is a strong consideration. …