Viral-deletion mutants that conditionally replicate and inhibit the wild-type virus (ie, defective
interfering particles, DIPs) have long been proposed as single-administration interventions …

Ca 2+ -dependent mechanisms are critical for successful completion of fertilization. Here,
we demonstrate that CRISP1, a sperm protein involved in mammalian fertilization, is also …

Cells make decisions based on a combination of external and internal signals. In yeast, the
high osmolarity response (HOG) is a mitogen-activated protein kinase (MAPK) pathway that …

Cells make accurate decisions in the face of molecular noise and environmental fluctuations
by relying not only on present pathway activity, but also on their memory of past signaling …

Rat epididymal CRISP1, the first described member of the evolutionarily conserved Cysteine‐RIch
Secretory Protein (CRISP) family, is expressed in the proximal regions of the …

According to receptor theory, the effect of a ligand depends on the amount of agonist–receptor
complex. Therefore, changes in receptor abundance should have quantitative effects. …

Cell signaling systems sense and respond to ligands that bind cell surface receptors. These
systems often respond to changes in the concentration of extracellular ligand more rapidly …

The high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
is a primary driver of the COVID-19 pandemic. While existing interventions prevent severe …

Epididymal protein CRISPI is a member of the CRISP (Cysteine-RIch Secretory proteins)
family and is involved in sperm-egg fusion through its interaction with complementary sites on …

Lectin‐glycan recognition systems play central roles in many physiologic and pathologic
processes. We identified a role for galectin‐1 (Gal‐1), a highly conserved glycan‐binding …