[HTML][HTML] Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry
The enveloped alphaviruses include important and emerging human pathogens such as
Chikungunya virus and Eastern equine encephalitis virus. Alphaviruses enter cells by clathrin-…
Chikungunya virus and Eastern equine encephalitis virus. Alphaviruses enter cells by clathrin-…
[HTML][HTML] Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus
P Shang, JD Simpson, GM Taylor… - Nature …, 2023 - nature.com
Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac
disease in humans. In mice, reovirus infects the intestine and disseminates systemically to …
disease in humans. In mice, reovirus infects the intestine and disseminates systemically to …
The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells
…, B Fitzgerald, L Hedden, K Fiske, GM Taylor… - Immunity, 2023 - cell.com
Loss of oral tolerance (LOT) to gluten, driven by dendritic cell (DC) priming of gluten-specific
T helper 1 (Th1) cell immune responses, is a hallmark of celiac disease (CeD) and can be …
T helper 1 (Th1) cell immune responses, is a hallmark of celiac disease (CeD) and can be …
Ubiquitin depletion and dominant-negative VPS4 inhibit rhabdovirus budding without affecting alphavirus budding
GM Taylor, PI Hanson, M Kielian - Journal of virology, 2007 - Am Soc Microbiol
The budding reactions of a number of enveloped viruses use the cellular machinery involved
in the formation of the luminal vesicles of endosomal multivesicular bodies (MVB). Budding …
in the formation of the luminal vesicles of endosomal multivesicular bodies (MVB). Budding …
Fv-4: identification of the defect in Env and the mechanism of resistance to ecotropic murine leukemia virus
GM Taylor, Y Gao, DA Sanders - Journal of virology, 2001 - Am Soc Microbiol
Mice expressing the Fv-4 gene are resistant to infection by ecotropic murine leukemia
viruses (MuLVs). TheFv-4 gene encodes an envelope (Env) protein whose putative receptor-…
viruses (MuLVs). TheFv-4 gene encodes an envelope (Env) protein whose putative receptor-…
NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein
…, JJ Knowlton, GM Taylor… - Proceedings of the …, 2023 - National Acad Sciences
Nogo-66 receptor 1 (NgR1) binds a variety of structurally dissimilar ligands in the adult
central nervous system to inhibit axon extension. Disruption of ligand binding to NgR1 and …
central nervous system to inhibit axon extension. Disruption of ligand binding to NgR1 and …
Disruption of Type III Interferon (IFN) Genes Ifnl2 and Ifnl3 Recapitulates Loss of the Type III IFN Receptor in the Mucosal Antiviral Response
…, EA Kennedy, PH Brigleb, GM Taylor… - Journal of …, 2019 - Am Soc Microbiol
Type III interferon (IFN), or IFN lambda (IFN-λ), is an essential component of the innate immune
response to mucosal viral infections. In both the intestine and the lung, signaling via the …
response to mucosal viral infections. In both the intestine and the lung, signaling via the …
[HTML][HTML] NK cells contribute to reovirus-induced IFN responses and loss of tolerance to dietary antigen
PH Brigleb, E Kouame, KL Fiske, GM Taylor… - JCI insight, 2022 - ncbi.nlm.nih.gov
Celiac disease is an immune-mediated intestinal disorder that results from loss of oral
tolerance (LOT) to dietary gluten. Reovirus elicits inflammatory Th1 cells and suppresses Treg …
tolerance (LOT) to dietary gluten. Reovirus elicits inflammatory Th1 cells and suppresses Treg …
Reovirus nonstructural protein σNS recruits viral RNA to replication organelles
CH Lee, K Raghunathan, GM Taylor, AJ French… - Mbio, 2021 - Am Soc Microbiol
The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic.
σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound …
σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound …
[HTML][HTML] Structure of orthoreovirus RNA chaperone σNS, a component of viral replication factories
…, CH Lee, X Somoulay, B Sankaran, GM Taylor… - Nature …, 2024 - nature.com
The mammalian orthoreovirus (reovirus) σNS protein is required for formation of replication
compartments that support viral genome replication and capsid assembly. Despite its …
compartments that support viral genome replication and capsid assembly. Despite its …