Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain
cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for …

Purpose: Targeting RAF for antitumor therapy in RAS-mutant tumors holds promise. Herein,
we describe in detail novel properties of the type II RAF inhibitor, LXH254. Experimental …

Baculovirus-insect cell expression system has become one of the most widely used
eukaryotic expression systems for heterologous protein production in many laboratories. The …

The design of cereblon-binding molecular glues (MGs) that selectively recruit a desired
protein while excluding teratogenic SALL4 is an area of significant interest when designing …

RAS mutations lead to a constitutively active oncogenic protein that signals through multiple
effector pathways. In this chemical biology study, we describe a novel coupled biochemical …

ATR, a protein kinase in the PIKK family, plays a critical role in the cell DNA-damage response
and is an attractive anticancer drug target. Several potent and selective inhibitors of ATR …

The allosteric inhibitor of the mechanistic target of rapamycin (mTOR) everolimus reduces
seizures in tuberous sclerosis complex (TSC) patients through partial inhibition of mTOR …

Members of the ATP-dependent SWI/SNF chromatin remodeling complexes are among the
most frequently mutated genes in cancer, suggesting their dysregulation plays a critical role. …

Extracellular signal-regulated kinase 2 (ERK2) is a serine/threonine protein kinase involved
in many cellular programs, such as cell proliferation, differentiation, motility and programed …

Identification of constructs suitable for the recombinant protein production pipeline is a
bottleneck for structural genomics efforts, as most methods require purified proteins and/or are …