User profiles for Gyun Min Lee
 | Gyun Min LeeProfessor of Biological Sciences, KAIST Verified email at kaist.ac.kr Cited by 26342 |
CHO cells in biotechnology for production of recombinant proteins: current state and further potential
Recombinant Chinese hamster ovary cells (rCHO) cells have been the most commonly
used mammalian host for large-scale commercial production of therapeutic proteins. Recent …
used mammalian host for large-scale commercial production of therapeutic proteins. Recent …
Characterization of chimeric antibody producing CHO cells in the course of dihydrofolate reductase‐mediated gene amplification and their stability in the absence of …
…, NS Kim, CJ Ryu, HJ Hong, GM Lee - Biotechnology and …, 1998 - Wiley Online Library
Recombinant Chinese hamster ovary (CHO) cells expressing a high‐level of chimeric antibody
against S surface antigen of hepatitis B virus were obtained by co‐transfection of heavy …
against S surface antigen of hepatitis B virus were obtained by co‐transfection of heavy …
Development of recombinant Chinese hamster ovary cell lines for therapeutic protein production
SM Noh, M Sathyamurthy, GM Lee - Current opinion in chemical …, 2013 - Elsevier
Highlights • Overall explanation of cell line development scheme. • Comparison between
two expression systems (DHFR system and GS system). • Recent advances in high-throughput …
two expression systems (DHFR system and GS system). • Recent advances in high-throughput …
Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells
SK Yoon, JY Song, GM Lee - Biotechnology and …, 2003 - Wiley Online Library
To determine the effect of low culture temperature on erythropoietin (EPO) production in
recombinant Chinese hamster ovary (rCHO) cells, rCHO cells producing EPO (LGE10‐9‐27) …
recombinant Chinese hamster ovary (rCHO) cells, rCHO cells producing EPO (LGE10‐9‐27) …
COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity
Angiopoietin-1 (Ang1) has potential therapeutic applications in inducing angiogenesis,
enhancing endothelial cell survival, and preventing vascular leakage. However, production of …
enhancing endothelial cell survival, and preventing vascular leakage. However, production of …
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2
…, N Ekman, M Marron, N Brindle, GM Lee… - The Journal of cell …, 2005 - rupress.org
The Tie1 receptor tyrosine kinase was isolated over a decade ago, but so far no ligand has
been found to activate this receptor. Here, we have examined the potential of angiopoietins, …
been found to activate this receptor. Here, we have examined the potential of angiopoietins, …
Biological characterization of angiopoietin‐3 and angiopoietin‐4
HJ Lee, CH Cho, SJ Hwang, HH Choi… - The FASEB …, 2004 - Wiley Online Library
The angiopoietin (Ang) family of growth factors includes Ang1, Ang2, Ang3, and Ang4, all of
which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) and Ang4 (human…
which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) and Ang4 (human…
[HTML][HTML] Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2
…, RA Kammerer, SY Ahn, HZ Kim, GM Lee… - Journal of Biological …, 2005 - ASBMB
Angiopoietin-1 (Ang1) is an essential molecule for blood vessel formation; however, little is
known about the structure-function relationships of Ang1 with its receptor, Tie2 (tyrosine …
known about the structure-function relationships of Ang1 with its receptor, Tie2 (tyrosine …
Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin
SH Kim, GM Lee - Applied microbiology and biotechnology, 2007 - Springer
Lactate, one of the major waste products in mammalian cell culture, can inhibit cell growth
and affect cellular metabolism at high concentrations. To reduce lactate formation, lactate …
and affect cellular metabolism at high concentrations. To reduce lactate formation, lactate …
Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37.0 C
…, SL Choi, JY Song, GM Lee - Biotechnology and …, 2005 - Wiley Online Library
To investigate the effect of culture pH in the range of 6.85–7.80 on cell growth and erythropoietin
(EPO) production at 32.5 and 37.0C, serum‐free suspension cultures of recombinant …
(EPO) production at 32.5 and 37.0C, serum‐free suspension cultures of recombinant …