The CRISPR–Cas system is a powerful genome editing tool that functions in a diverse array
of organisms and cell types. The technology was initially developed to induce targeted …

Translation initiation is often attributed as the rate-determining step of eukaryotic protein
synthesis and key to gene expression control. Despite this centrality, the series of steps involved …

Advances in genomics and molecular biology have revealed an abundance of small open
reading frames (sORFs) across all types of transcripts. While these sORFs are often assumed …

Background With the rapid growth in the use of high-throughput methods for characterizing
translation and the continued expansion of multi-omics, there is a need for back-end …

The application of ribosome profiling has revealed an unexpected abundance of translation
in addition to that responsible for the synthesis of previously annotated protein-coding …

Fabry disease (FD) is an X-linked inborn metabolic disorder due to partial or complete
lysosomal α-galactosidase A deficiency. FD is characterized by progressive renal insufficiency …

Upstream open reading frames (uORFs) are in frame start and stop codons starting in the 5’
leader of mRNAs. They have been found to regulate gene expression, primarily through …

Translation initiation is often attributed as the rate determining step of eukaryotic protein
synthesis and key to gene expression control 1 . Despite this centrality the series of steps …

… I am also to my co-supervisor Håkon Tjeldnes for invaluable technical and hands-on …
September 2019 with Professor Eivind Valen as supervisor and Håkon Tjeldnes as co-supervisor. …

… Thank you, Dimitris Kleftogiannis and Pattama Wapeesittipan, for your scientific input and
friendship, Hakon Tjeldnes and David Dolan for guiding me through my baby steps in R and …