Upon antigen recognition, T cells form either static (synapses) or migratory (kinapses)
contacts with antigen-presenting cells. Addressing whether synapses and kinapses result in …

The function of most immune cells depends on their ability to migrate through complex
microenvironments, either randomly to patrol for the presence of antigens or directionally to reach …

The migration of immune cells can be guided by physical cues imposed by the environment,
such as geometry, rigidity, or hydraulic resistance (HR). Neutrophils preferentially follow …

T lymphocytes are highly motile cells that decelerate upon antigen recognition. These cells
can either completely stop or maintain a low level of motility, forming contacts referred to as …

CD8 + T cell responses generate effector cells endowed with distinct functional potentials
but the contribution of early events in this process is unclear. Here, we have imaged T cells …

Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes to initiate adaptive
immune responses. Within tissues, DCs constitute a complex cell population composed of …

Ten years ago, in 2002, the introduction of dynamic in vivo imaging to immunologists set a
new standard for studying immune responses. In particular, two-photon imaging has provided …

… Author links open overlay panel Hélène D Moreau 1 2 3 , Philippe Bousso 1 2 … (d) NFAT
translocation in T cells can be imaged by the combined expression of fluorescent NFAT and …

Contraction is a critical phase of immunity whereby the vast majority of effector T cells die by
apoptosis, sparing a population of long-lived memory cells. Where, when, and why …

Targeting TLR3 through formulations of polyI:C is widely studied as an adjuvant in cancer
immunotherapy. The efficacy of such targeting has been shown to increase in combination …