Genome-wide association studies (GWAS) in psychiatry, once they reach sufficient sample
size and power, have been enormously successful. The Psychiatric Genomics Consortium (…

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …

With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia
have not converged on findings that can be confidently used for precise experimental …

Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30–60%.
We conducted a genome-wide association study of Lifetime Anxiety Disorder (n case = …

The predictive utility of polygenic scores is increasing, and many polygenic scoring methods
are available, but it is unclear which method performs best. This study evaluates the …

Depression is more frequent among individuals exposed to traumatic events. Both trauma
exposure and depression are heritable. However, the relationship between these traits, …

Background Mood disorders (including major depressive disorder and bipolar disorder)
affect 10% to 20% of the population. They range from brief, mild episodes to severe, …

Background The heterogeneity of genetic effects on major depressive disorder (MDD) may
be partly attributable to moderation of genetic effects by environment, such as exposure to …