[HTML][HTML] The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes
…, HKM Vollan, E Provenzano, HA Bardwell… - Nature …, 2016 - nature.com
The genomic landscape of breast cancer is complex, and inter-and intra-tumour heterogeneity
are important challenges in treating the disease. In this study, we sequence 173 genes in …
are important challenges in treating the disease. In this study, we sequence 173 genes in …
[HTML][HTML] Multi-omic machine learning predictor of breast cancer therapy response
…, SF Chin, E Provenzano, HA Bardwell… - Nature, 2022 - nature.com
Breast cancers are complex ecosystems of malignant cells and the tumour microenvironment
1 . The composition of these tumour ecosystems and interactions within them contribute to …
1 . The composition of these tumour ecosystems and interactions within them contribute to …
[HTML][HTML] Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer
…, J Wesseling, E Kay, SJ Sammut, HA Bardwell… - Scientific reports, 2016 - nature.com
Invasive lobular carcinoma (ILC) is the second most frequently occurring histological breast
cancer subtype after invasive ductal carcinoma (IDC), accounting for around 10% of all …
cancer subtype after invasive ductal carcinoma (IDC), accounting for around 10% of all …
Therapeutic rationale to target highly expressed CDK7 conferring poor outcomes in triple-negative breast cancer
Triple-negative breast cancer (TNBC) patients commonly exhibit poor prognosis and high
relapse after treatment, but there remains a lack of biomarkers and effective targeted therapies …
relapse after treatment, but there remains a lack of biomarkers and effective targeted therapies …
[HTML][HTML] Shallow whole genome sequencing for robust copy number profiling of formalin-fixed paraffin-embedded breast cancers
…, M Pugh, MA Goldgraben, HA Bardwell… - … and molecular pathology, 2018 - Elsevier
Pathology archives with linked clinical data are an invaluable resource for translational
research, with the limitation that most cancer samples are formalin-fixed paraffin-embedded (…
research, with the limitation that most cancer samples are formalin-fixed paraffin-embedded (…
[PDF][PDF] KDM2B recruitment of the polycomb group complex, PRC1. 1, requires cooperation between PCGF1 and BCORL1
KDM2B recruits H2A-ubiquitinating activity of a non-canonical Polycomb Repression Complex
1 (PRC1.1) to CpG islands, facilitating gene repression. We investigated the molecular …
1 (PRC1.1) to CpG islands, facilitating gene repression. We investigated the molecular …
Abstract B06: CDK7: A marker of poor prognosis and tractable therapeutic target in triple-negative breast cancer
…, GM Udupi, A Gaber, SF Chin, HA Bardwell… - Molecular Cancer …, 2016 - AACR
Triple-negative breast cancer (TNBC) represents a heterogeneous subgroup of breast cancer
with substantial genotypic and phenotypic diversity. TNBC patients commonly exhibit poor …
with substantial genotypic and phenotypic diversity. TNBC patients commonly exhibit poor …
A signaling mucin at the head of the Cdc42-and MAPK-dependent filamentous growth pathway in yeast
…, C Neal, J Delrow, L Bardwell… - Genes & …, 2004 - genesdev.cshlp.org
Signaling molecules such as Cdc42 and mitogen-activated protein kinases (MAPKs) can
function in multiple pathways in the same cell. Here, we propose one mechanism by which …
function in multiple pathways in the same cell. Here, we propose one mechanism by which …
Association between cancer stigma and depression among cancer survivors: a nationwide survey in Korea
…, C Kim, DH Koh, E Guallar, WA Bardwell… - Psycho …, 2013 - Wiley Online Library
Objective Cancer patients are more likely to experience depression than the general
population. This study aims to evaluate the possible association between cancer stigma and …
population. This study aims to evaluate the possible association between cancer stigma and …
[HTML][HTML] Towards crystal structure prediction of complex organic compounds–a report on the fifth blind test
DA Bardwell, CS Adjiman, YA Arnautova… - … Section B: Structural …, 2011 - scripts.iucr.org
Following on from the success of the previous crystal structure prediction blind tests (CSP1999,
CSP2001, CSP2004 and CSP2007), a fifth such collaborative project (CSP2010) was …
CSP2001, CSP2004 and CSP2007), a fifth such collaborative project (CSP2010) was …