Obesity is commonly associated with the development of insulin resistance and diabetes in
humans and rodents. Insulin resistance and diabetes are observed in lipoatrophic …

The glucose transport proteins (GLUT1 and GLUT4) facilitate glucose transport into insulin-sensitive
cells. GLUT1 is insulin-independent and is widely distributed in different tissues. …

Background The incidence of hematologic cancers increases with age. These cancers are
associated with recurrent somatic mutations in specific genes. We hypothesized that such …

Type 2 (non-insulin-dependent) diabetes mellitus afflicts millions of people worldwide and is
one of the main causes of morbidity and mortality. Current therapeutic agents to treat Type 2 …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum,
we conducted a meta-analysis of genome-wide association data from 26,676 T2D case …

We screened variants on an exome-focused genotyping array in> 300,000 participants (replication
in> 280,000 participants) and identified 444 independent variants in 250 loci …

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …

We identified signaling pathways by which IL-6 regulates skeletal muscle differentiation and
metabolism. Primary human skeletal muscle cells were exposed to IL-6 (25 ng/ml either …

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with …