… 7 and on the products of the translocation, the derived chromosome 5 (der 5) and derived
chromosome 7 (der 7). (D) Southern blot analysis with genomic DNA from the … van der Linde …

Lack of fragile X mental retardation protein (FMRP) causes Fragile X Syndrome, the most
common form of inherited mental retardation. FMRP is an RNA-binding protein and is a …

… Elle KJ Risse and Hans C van der Linden were responsible for the reading of cytology and
histology. Peter Kenemans and Theo JM Helmerhorst participated in the assessment of the …

Microglia are CNS-resident macrophages that scavenge debris and regulate immune
responses. Proliferation and development of macrophages, including microglia, requires Colony …

… van der Linde,1 Saskia M. Burm,2 Woutje Berdowski,1 Wilfred FJ van Ijcken,3 John C. …
van Ham1,8,* 1Department of Clinical Genetics, Erasmus MC, University Medical Center …

The human FMR1 gene contains a CGG repeat in its 5′ untranslated region. The repeat
length in the normal population is polymorphic (5–55 CGG repeats). Lengths beyond 200 …

Fragile X syndrome, the most common form of inherited intellectual disability, is caused by a
lack of FMRP, which is the product of the Fmr1 gene. FMRP is an RNA-binding protein and …

Microglia are brain resident macrophages important for brain development, connectivity,
homeostasis and disease. However, it is still largely unclear how microglia functions and their …

Background Hirschsprung disease (HSCR), which is congenital obstruction of the bowel,
results from a failure of enteric nervous system (ENS) progenitors to migrate, proliferate, …

Tissue-resident macrophages of the brain, including microglia, are implicated in the
pathogenesis of various CNS disorders and are possible therapeutic targets by their chemical …