Integration is vital to retroviral replication and influences the establishment of the latent HIV
reservoir. HIV-1 integration favors active genes, which is in part determined by the interaction …

HIV-1 integration into the host genome favors actively transcribed genes. Prior work indicated
that the nuclear periphery provides the architectural basis for integration site selection, …

The quinoline-based allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are promising
candidates for clinically useful antiviral agents. Studies using these compounds have highlighted …

The host chromatin-binding factor LEDGF/p75 interacts with HIV-1 integrase and directs
integration to active transcription units. To understand how LEDGF/p75 recognizes transcription …

Using data from 23,313 patients, we assessed whether two blood culture sets of three
bottles per set would detect more pathogens than two sets of two bottles per set and achieve …

HIV-1 utilizes the cellular protein LEDGF/p75 as a chromosome docking and integration
cofactor. The LEDGF/p75 gene, PSIP1, is a potential therapeutic target because, like CCR5, …

The large nucleoporin Nup358/RanBP2 forms eight filaments that project from the nuclear
pore into the cytoplasm where they function as docking platforms for nucleocytoplasmic …

Influenza is a global problem infecting 5–10% of adults and 20–30% of children annually.
Non-pharmaceutical interventions (NPIs) are attractive approaches to complement vaccination …

Objective To report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19)
related to patient outcomes. Methods We conducted a retrospective chart review of patients …

Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed
that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and …