S-nitrosation, commonly referred to as S-nitrosylation, is widely regarded as a ubiquitous,
stable post-translational modification that directly regulates many proteins. Such a widespread …

Background Ovarian cancer has a poor survival rate due to late diagnosis and improved
methods are needed for its early detection. Our primary objective was to identify and …

Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to
optimize allocation of treatment and resources in intensive care, as clinically established risk …

Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of
human disease is a key obstacle to drug development. We present a biomimetic model of …

Protein methylation is a key post-translational modification whose effects on gene expression
have been intensively studied over the last two decades. Recently, renewed interest in non…

Pulmonary epithelial cell responses can enhance type 2 immunity and contribute to control
of nematode infections. An important epithelial product is the collectin Surfactant Protein D (…

Prediction and diagnosis of complex disease may not always be possible with a small number
of biomarkers. Modern ‘omics’ technologies make it possible to cheaply and quantitatively …

Biological aging is a complex process involving multiple biological processes. These can
be understood theoretically though considering them as individual networks – eg epigenetic …

… Whitwell … Whitwell and John F. Timms performed data analysis and Joy Cuenco conducted
… -Shabrawi, A.; Quehenberger, F.; Mischinger, HJ TUM2-PK (pyruvate kinase type tumor M2), …

Streptococcus pyogenes genotype emm1 is a successful, globally distributed epidemic
clone that is regarded as inherently virulent. An emm1 sublineage, M1 UK , that produces …